Emily R Siniscalco, Adam Williams, Stephanie C Eisenbarth
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引用次数: 0
Abstract
The increasing prevalence of food allergy and related pathologies in recent years has underscored the need to understand the factors affecting adverse reactions to food. Food allergy is caused when food-specific IgE triggers the release of histamine from mast cells. However, other food-specific antibody isotypes exist as well, including IgG and IgA. IgA is the main antibody isotype in the gut and mediates noninflammatory reactions to toxins, commensal bacteria, and food antigens. It has also been thought to induce tolerance to food, thus antagonizing the role of food-specific IgE. However, this has remained unclear as food-specific IgA generation is poorly understood. Particularly, the location of IgA induction, the role of T cell help, and the fates of food-specific B cells remain elusive. In this review, we outline what is known about food-specific IgA induction and highlight areas requiring further study. We also explore how knowledge of food-specific IgA induction can be informed by and subsequently contribute to our overall knowledge of gut immunity.
近年来,食物过敏和相关病症的发病率不断上升,这凸显了了解影响食物不良反应因素的必要性。食物特异性 IgE 触发肥大细胞释放组胺,从而引起食物过敏。不过,也存在其他食物特异性抗体异型,包括 IgG 和 IgA。IgA 是肠道中的主要抗体同工型,可介导对毒素、共生细菌和食物抗原的非炎症反应。人们还认为 IgA 能诱导对食物的耐受性,从而抵消食物特异性 IgE 的作用。然而,由于人们对食物特异性 IgA 的产生还知之甚少,因此这一点仍不清楚。特别是,IgA 诱导的位置、T 细胞帮助的作用以及食物特异性 B 细胞的命运仍然难以捉摸。在这篇综述中,我们概述了有关食物特异性 IgA 诱导的已知知识,并强调了需要进一步研究的领域。我们还探讨了如何通过食物特异性 IgA 诱导的知识来了解肠道免疫的整体知识,进而为这些知识做出贡献。
期刊介绍:
Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system.
The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.