AUDIT C compared to PEth in middle-aged volunteers.

IF 2.1 4区医学 Q3 SUBSTANCE ABUSE Alcohol and alcoholism Pub Date : 2024-07-21 DOI:10.1093/alcalc/agae048

Marie Fredriksson, Mårten Werner

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Abstract

Aims: To compare Alcohol Use Disorders Identification Test (AUDIT C) to phosphatidylethanol (PEth) in middle-aged randomly selected volunteers. Apply previously suggested lower cut-offs for PEth using moderate alcohol intake according to AUDIT C as a reference.

Methods: Within the Swedish CardioPulmonary BioImage Study, 2255 middle-aged (50-64 years of age) volunteers in northern Sweden participated in comparing AUDIT C to PEth 16:0/18:1.

Results: There was a moderate correlation between PEth 16:0/18:1 and AUDIT C (r = 0.66). None of the participants with the AUDIT C-score 0 had a measurable PEth. Of moderate alcohol consumers, according to AUDIT C (AUDIT C 1-3 women, 1-4 men), 96% had a PEth below 0.3 μmol/L, 91% had a PEth below 0.16 μmol/L, and 84% had a PEth below 0.11 μmol/L. With PEth equivalent to excessive alcohol consumption (≥0.3 μmol/L), 26% had an AUDIT C-score below excessive alcohol consumption (<4 for women and <5 for men). Thirty percent of patients with a PEth ≥0.16 μmol/L had an AUDIT C-score below excessive alcohol consumption, and 37% had a PEth ≥0.11 μmol/L. We found no significant correlation between BMI and PEth or AUDIT C.

Conclusions: There is a significant correlation between AUDIT C and PEth. Using AUDIT C alone, 26% of high-consumers, according to PEth, are not found in our cohort, but an AUDIT C-score of 0 will exclude high consumption, according to PEth. Our findings support the current cut-off for PEth of 0.3 μmol/L, but a lower cut-off seems reasonable.

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中年志愿者的 AUDIT C 与 PEth 的比较。

目的：比较随机抽取的中年志愿者的酒精使用障碍识别测试（AUDIT C）和磷脂酰乙醇（PEth）。以 AUDIT C 中度酒精摄入量为参考，采用之前建议的 PEth 较低临界值：方法：在瑞典心肺生物图像研究中，瑞典北部的 2255 名中年（50-64 岁）志愿者参与了 AUDIT C 与 PEth 16:0/18:1 的比较：结果：PEth 16:0/18:1 与 AUDIT C 之间存在中度相关性（r = 0.66）。在 AUDIT C 分数为 0 的参与者中，没有人有可测量的 PEth。根据 AUDIT C（AUDIT C 1-3 女性，1-4 男性），在中度饮酒者中，96% 的 PEth 低于 0.3 μmol/L，91% 的 PEth 低于 0.16 μmol/L，84% 的 PEth 低于 0.11 μmol/L。PEth相当于过量饮酒（≥0.3 μmol/L）时，26%的人的AUDIT C评分低于过量饮酒（结论：AUDIT C 和 PEth 之间存在明显的相关性。仅使用 AUDIT C，根据 PEth，我们的队列中没有发现 26% 的高饮酒量者，但根据 PEth，AUDIT C 得分为 0 则可排除高饮酒量者。我们的研究结果支持目前 0.3 μmol/L 的 PEth 临界值，但更低的临界值似乎也是合理的。

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来源期刊

Alcohol and alcoholism 医学-药物滥用

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

4-8 weeks

期刊介绍： About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.