The implicated role of GDF15 in gastrointestinal cancer

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL European Journal of Clinical Investigation Pub Date : 2024-07-23 DOI:10.1111/eci.14290

Yingqi Xue, Yan Zhang, Yale Su, Jiangqi Zhao, Daoquan Yu, Yunju Jo, Jongkil Joo, Hyun Joo Lee, Dongryeol Ryu, Shibo Wei

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Abstract

Background

Growth differentiation factor 15 (GDF15), a stress-responsive cytokine from transforming growth factor superfamily, is highly expressed in mammalian tissues, including pancreas, stomach and intestine under pathological conditions. In particular, elevated levels of GDF15 might play an important role in the development and progression of various gastrointestinal cancers (GCs), suggesting its potential as a promising target for disease prediction and treatment.

Methods

In this review, systematic reviews addressing the role of GDF15 in GCs were updated, along with the latest clinical trials focussing on the GDF15-associated digestive malignancies.

Results

The multiple cellular pathways through which GDF15 is involved in the regulation of physiological and pathological conditions were first summarized. Then, GDF15 was also established as a valuable clinical index, functioning as a predictive marker in diverse GCs. Notably, latest clinical treatments targeting GDF15 were also highlighted, demonstrating its promising potential in mitigating and curing digestive malignancies.

Conclusions

This review unveils the pivotal roles of GDF15 and its potential as a promising target in the pathogenesis of GCs, which may provide insightful directions for future investigations.

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GDF15 在胃肠癌中的作用。

背景：生长分化因子15（GDF15）是转化生长因子超家族中的一种应激反应细胞因子，在哺乳动物组织（包括病理情况下的胰腺、胃和肠）中高表达。特别是，GDF15水平的升高可能在各种胃肠道癌症（GCs）的发生和发展过程中发挥重要作用，这表明它有可能成为疾病预测和治疗的潜在靶点：本综述更新了有关GDF15在GCs中作用的系统综述，以及与GDF15相关的消化道恶性肿瘤的最新临床试验：结果：首先总结了GDF15参与调节生理和病理状态的多种细胞通路。然后，GDF15还被确定为一种有价值的临床指标，可作为多种消化道恶性肿瘤的预测标志物。值得注意的是，针对 GDF15 的最新临床治疗方法也得到了强调，显示了其在缓解和治愈消化系统恶性肿瘤方面的巨大潜力：本综述揭示了 GDF15 在 GCs 发病机制中的关键作用及其作为潜在靶点的潜力，这可能为未来的研究提供了具有洞察力的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.