Association between thyroid hormone resistance and obesity: a cross-sectional study and mouse stimulation test

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2024-07-24 DOI:10.1002/oby.24084

Zhihui Wang, Huimin Yu, Kai Wang, Junming Han, Yongfeng Song

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Abstract

Objective

Thyroid hormone influences key metabolic pathways, and reduced sensitivity to thyroid hormone is considered a new risk factor for adverse metabolic outcomes. However, the association between thyroid hormone resistance and obesity in euthyroid individuals is still unknown.

Methods

We enrolled 8021 euthyroid individuals, calculated thyroid hormone resistance indices, and analyzed the association between thyroid hormone resistance and obesity by regression analysis. Furthermore, we conducted the thyrotropin-releasing hormone stimulation test in both control and obese mice (n = 5) to demonstrate the association.

Results

The euthyroid adults with overweight and obesity had increased thyroid hormone resistance indices (all p < 0.05). BMI and prevalence of overweight and obesity increased (odds ratio of thyroid feedback quantile-based index [OR_TFQI] = 1.164, p = 0.036; OR of free triiodothyronine/free thyroxine [OR_FT3/FT4] = 1.508, p < 0.001) following the elevation of thyroid hormone resistance indices. Mediation analysis indicated a complete mediation effect (beta coefficient of indirect effect [β_Ind]= 6.838, p < 0.001) of metabolic disorders in the relationship. Furthermore, in the mice with obesity, the thyrotropin response to thyrotropin-releasing hormone stimulation (68.33–90.89 pg/mL) was comparatively blunted (p = 0.029).

Conclusions

Euthyroid individuals with obesity exhibit both central and peripheral thyroid hormone resistance, a phenomenon that is more pronounced in individuals with metabolic abnormalities. Thyroid hormone resistance is associated with an increased prevalence of overweight and obesity mediated by metabolic disorders.

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甲状腺激素抵抗与肥胖之间的关系：一项横断面研究和小鼠刺激试验。

目的：甲状腺激素影响关键的代谢途径，对甲状腺激素的敏感性降低被认为是导致不良代谢结果的新风险因素。然而，甲状腺激素抵抗与甲状腺功能正常者肥胖之间的关系仍然未知：我们招募了 8021 名甲状腺功能正常者，计算了甲状腺激素抵抗指数，并通过回归分析分析了甲状腺激素抵抗与肥胖之间的关系。此外，我们还对对照组小鼠和肥胖小鼠（5 只）进行了促甲状腺激素释放激素刺激试验，以证明两者之间的关联：结果：患有超重和肥胖症的甲状腺功能正常成人的甲状腺激素抵抗指数增加（所有 p TFQI] = 1.164，p = 0.036；游离三碘甲状腺原氨酸/游离甲状腺素 OR [ORFT3/FT4] = 1.508，p Ind]= 6.838，p 结论：甲状腺功能正常的肥胖症患者的甲状腺激素抵抗指数增加：甲状腺功能正常的肥胖症患者同时表现出中枢和外周甲状腺激素抵抗，这一现象在代谢异常的患者中更为明显。甲状腺激素抵抗与代谢紊乱导致的超重和肥胖发生率增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.