Expression of Concern: HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8

Abstract

Chen, Y., Zhao, F., Cui, D., Jiang, R., Chen, J., Huang, Q. and Shi, J. (2018), HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8. Int. J. Cancer, 142: 2313–2322. https://doi.org/10.1002/ijc.31262.

This Expression of Concern is for the above article, published online on 17 January 2018 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Christoph Plass, the Union for International Cancer Control and John Wiley & Sons, Ltd.

The Expression of Concern has been agreed due to concerns raised by third parties regarding the data presented in Figure 5b and 5c. Specifically, the si-NC panel in Figure 5b (cell migration) appears to overlap with the si-NC panel in Figure 5c (cell invasion) when rotated. The authors acknowledged that the image for si-NC in Figure 5c was mislabeled and that they were no longer able to locate the original image underlying si-NC in Figure 5c due to problems with data storage. Additionally, it has come to the attention of the journal that in Figure 4c the blots displaying the loading control β-actin do not originate from the same blots where E2F7 and E2F8 were detected. The authors have indicated that E2F7, E2F8, and β-actin expression levels were detected on different membranes. However, they assure that the same experimental protocol was rigorously followed. The journal has issued this Expression of Concern to inform and alert readers.