Communication: High-Density Lipoprotein-Specific Phospholipid Efflux in Familial Hypercholesterolemia.

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Annals of clinical and laboratory science Pub Date : 2024-05-01

Masaki Sato, Masato Hamasaki, Edward B Neufeld, Alan T Remaley, Kazuhiko Kotani

引用次数: 0

Abstract

Objective: Familial hypercholesterolemia (FH) is characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD). Although the role of LDL-C in FH has been studied, the contribution of high-density lipoproteins (HDL) to CVD in FH remains unknown. This study aimed at highlighting the role of HDL in FH.

Methods: HDL-specific phospholipid efflux (HDL-SPE) assay was developed to predict CVD risk. HDL-SPE was examined in FH patients (n=30) and compared with age- and sex-matched non-FH controls (n=60).

Results: FH patients had significantly lower HDL-SPE levels (0.90±0.12) than controls (1.12±0.10; p<0.05), despite similar HDL-cholesterol levels in both groups (FH: 57.9±18.7 mg/dl; controls: 57.1±13.8 mg/dl). These differences remained significant after adjusting for confounders.

Conclusions: These findings suggest there may be dysfunctionality of HDL in FH.

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交流：家族性高胆固醇血症中的高密度脂蛋白特异性磷脂外流。

目的：家族性高胆固醇血症（FH家族性高胆固醇血症（FH）的特点是低密度脂蛋白胆固醇（LDL-C）水平升高和心血管疾病（CVD）。虽然低密度脂蛋白胆固醇在 FH 中的作用已得到研究，但高密度脂蛋白（HDL）对 FH 中心血管疾病的贡献仍不清楚。本研究旨在强调高密度脂蛋白在 FH 中的作用。对 FH 患者（30 人）的 HDL-SPE 进行检测，并与年龄和性别匹配的非 FH 对照组（60 人）进行比较：结果：FH 患者的 HDL-SPE 水平（0.90±0.12）明显低于对照组（1.12±0.10；p结论：这些研究结果表明，FH 患者的 HDL-SPE 可能存在功能障碍：这些研究结果表明，FH 患者的 HDL 可能存在功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of clinical and laboratory science 医学-医学实验技术

CiteScore

1.60

自引率

0.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： The Annals of Clinical & Laboratory Science welcomes manuscripts that report research in clinical science, including pathology, clinical chemistry, biotechnology, molecular biology, cytogenetics, microbiology, immunology, hematology, transfusion medicine, organ and tissue transplantation, therapeutics, toxicology, and clinical informatics.