Long-term outcomes following bioresorbable vascular scaffolds.

IF 1.8 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Expert Review of Cardiovascular Therapy Pub Date : 2024-08-01 Epub Date: 2024-07-30 DOI:10.1080/14779072.2024.2375340
Kotaro Miyashita, Kai Ninomiya, Akihiro Tobe, Shinichiro Masuda, Nozomi Kotoku, Shigetaka Kageyama, Pruthvi C Revaiah, Tsung-Ying Tsai, Bo Wang, Scot Garg, Patrick W Serruys, Yoshinobu Onuma
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Abstract

Introduction: The higher scaffold thrombosis rates observed with the first-generation bioresorbable scaffolds (BRSs) compared to conventional drug-eluting stents were likely due in part to bioresorbable polymers having insufficient radial strength, necessitating larger strut profiles. Meta-analysis of the long-term outcomes from the first-generation Absorb bioresorbable vascular scaffold (BVS) showed that this period of excess risk ended at 3 years. Therefore, current attention has been focused on improving early outcomes by increasing the scaffold's tensile strength and reducing strut thickness.

Areas covered: This review summaries the lessons learned from the first-generation BRS. It updates the long-term clinical outcomes of trials evaluating the ABSORB BVS and metallic alloy-based BRS. In addition, it reviews the next-generation BRSs manufactured in Asia.

Expert opinion: Critical areas to improve the performance and safety of biodegradable scaffolds include further development in material science, surface modification, delivery systems, and long-term follow-up studies.

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生物可吸收血管支架的长期疗效。
简介:与传统的药物洗脱支架相比,第一代生物可吸收支架(BRS)的支架血栓形成率较高,部分原因可能是生物可吸收聚合物的径向强度不足,因此需要更大的支架轮廓。对第一代 Absorb 生物可吸收血管支架(BVS)的长期疗效进行的 Meta 分析表明,超额风险期在 3 年后结束。因此,目前的关注重点是通过提高支架的抗拉强度和减少支架厚度来改善早期疗效:本综述总结了第一代 BRS 的经验教训。它更新了评估 ABSORB BVS 和基于金属合金的 BRS 的试验的长期临床结果。此外,它还回顾了亚洲生产的下一代 BRS:提高生物可降解支架性能和安全性的关键领域包括材料科学、表面改性、输送系统和长期随访研究的进一步发展。
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来源期刊
Expert Review of Cardiovascular Therapy
Expert Review of Cardiovascular Therapy CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
0.00%
发文量
82
期刊介绍: Expert Review of Cardiovascular Therapy (ISSN 1477-9072) provides expert reviews on the clinical applications of new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage includes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery. The Expert Review format is unique. Each review provides a complete overview of current thinking in a key area of research or clinical practice.
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