Pon1 and Sult1a1 Polymorphisms and Breast Cancer Among Young Women in Brazil.

Abstract

Purpose: To investigate the association of genetic polymorphisms Gln¹⁹²Arg and Leu⁵⁵Met of Paraoxonase 1 (PON1) gene, and Arg²¹³His of Sulfotransferase 1A1 (SUT1A1) gene with occurrence of breast cancer among young women living in Rio de Janeiro city. Methods: This is a hospital-based case-control study including 265 women aged 18-35 years, diagnosed with breast cancer at National Cancer Institute; and 277 controls in the same age group selected among women patients and companions of three general hospitals from Rio de Janeiro public health network. Polymorphisms genotyping was performed using the PCR-RFLP technique. Results: For PON1 gene, breast cancer women had a greater chance of being homozygote for Leu⁵⁵Met polymorphism (OR_adjusted = 1.42, 95% CI= 0.67-3.00, recessive model) and a lower chance of having at least one allele of Gln¹⁹²Arg polymorphism (OR_adjusted = 0.75, 95% CI = 0.50-1.13, dominant model), but without statistical significance. Accordingly, frequency of the haplotype Met⁵⁵/Arg¹⁹² was lower among breast cancer women, but no statistically significant association was observed (OR_adjusted = 0.85; 95% CI = 0.48-1.51). SULT1A1 His/His genotype was significantly associated with a protective effect for breast cancer (OR _adjusted = 0.51, 95% CI = 0.28-0.91, recessive model). Conclusion: Arg²¹³His polymorphism of SUT1A1 gene showed a protective effect against breast cancer among Brazilian young women. More studies with different designs are needed to understand the role of PON1 and SULT1A1 polymorphisms in breast cancer development in young Brazilian women.