Weight Regain following Bariatric Surgery and in vitro Fertilization Outcomes.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Obesity Facts Pub Date : 2024-08-13 DOI:10.1159/000540388

Bar Zemer-Tov, Tomer Ziv-Baran, May Igawa, Gabriella Lieberman, Raoul Orvieto, Ronit Machtinger

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Abstract

Introduction: The aim of this study was to estimate the time to pregnancy and live birth and evaluate the effect of weight regain in women with a history of bariatric surgery (BS) who underwent in vitro fertilization (IVF) treatments.

Methods: This is a retrospective cohort study. All patients with previous BS who underwent IVF treatment in a tertiary university-affiliated hospital between 2013 and 2022 were included. Time to pregnancy and live birth were compared between patients who regained less than or greater than three points of body mass index (BMI) from the nadir weight after BS. Kaplan-Meier curves and log-rank tests were used to compare groups.

Results: A total of 78 patients were included in this study. The positive β-hCG, clinical pregnancy, and live birth rates following BS were 89.4%, 78.9%, and 50.8%, respectively. The median time from the beginning of IVF treatments to a positive β-hCG test was 2.97 months (95% CI: 1.04-4.89 months), to a clinical pregnancy was 7.1 months (95% CI: 3.56-10.91), and to a live birth was 20.2 months. Women who maintained their nadir BMI following BS had nearly twice the chance of achieving a clinical pregnancy (HR 1.967, 95% CI: 1.026-3.771, p = 0.042) and were approximately three times more likely to achieve a live birth (2.864, 95% CI: 1.196-6.859, p = 0.018) than those who regained at least three points of BMI.

Conclusion: Weight regain after BS is associated with a lower rate of live births and prolonged time to achieve clinical pregnancy and live birth.

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减肥手术后的体重恢复与体外受精结果

内容简介目的：估算曾接受减肥手术（BS）并接受体外受精（IVF）治疗的女性怀孕和活产的时间，并评估体重增加的影响：这是一项回顾性队列研究。方法：这是一项回顾性队列研究。研究纳入了2013年至2022年期间在一所大学附属三级医院接受体外受精治疗的所有曾接受过减肥手术的患者。比较了体重指数（BMI）从BS后的最低体重恢复少于或超过三个点的患者的妊娠时间和活产时间。采用卡普兰-梅耶曲线和对数秩检验对各组进行比较：结果：本研究共纳入 78 名患者。BS后β-hCG阳性率、临床妊娠率和活产率分别为89.4%、78.9%和50.8%。从开始试管婴儿治疗到β-hCG检测呈阳性的中位时间为2.97个月（95%CI为1.04-4.89个月），到临床妊娠的中位时间为7.1个月（95%CI为3.56-10.91个月），到活产的中位时间为20.2个月。与体重指数至少恢复三个百分点的妇女相比，BS 后保持最低体重指数的妇女临床妊娠的几率几乎是后者的两倍（HR 1.967，95%CI 1.026-3.771，p=0.042），活产的几率大约是后者的三倍（2.864，95%CI 1.196-6.859，p=0.018）：结论：BS 后体重反弹与活产率降低、临床妊娠和活产时间延长有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Facts 医学-内分泌学与代谢

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.