Carbon ion beam dosimetry in magnetic fields using Farmer-type ionization chambers of different radii: measurements and simulations.

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL Physics in medicine and biology Pub Date : 2024-10-15 DOI:10.1088/1361-6560/ad67a5
S Surla, M Marot, L Burigo, S Brons, A Runz, C P Karger
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Abstract

Objective.To investigate magnetic field effects on the dose distribution and ionization chambers response in carbon ion reference fields and determine magnetic field correction factors for chambers of different volumes.Approach.The response of six Farmer-type chambers with varying radii (1-6 mm, termed as R1-R6) was measured in magnetic fields up to 1 T in 0.1 T increments using an experimental electromagnet and compared with Monte Carlo simulations. Chamber readings were measured in the entrance region of a monoenergetic carbon ion beam of 390.75 MeV u-1. A lower energy of 200.28 MeV u-1was applied to chamber R3 for comparison. Polarity and recombination corrections were investigated for the R3 chamber. The local dose change induced by the magnetic field was calculated by Monte Carlo, which together with change of the chamber's response, was used to calculate the final magnetic field correction factors.Main results.The dependence of the chamber response on the magnetic field was non-linear and volume-dependent. Maximum changes ranged from 0.30% (R4) to 0.62% (R5) at 0.2 T. For R3, the response for the lower energy was systematically decreased by 0.2% in the range of 0.2 T to 0.7 T. No significant effect of the magnetic field on polarity and ion recombination correction was found. The maximum variation of the local dose was found to be (0.03 ± 0.08) % at 0.2 T for beam energy of 390.75 MeV u-1. Magnetic field correction factors for the different chambers ranged from 0.28% (R4) to 0.60% (R5).Significance.This study provides the first detailed analysis of chambers' response to magnetic flux densities of up to 1 T using chambers of different radii and comparison with simulations. By combining the chamber response alterations with local dose changes magnetic field correction factors were calculated for all six chambers, including the commercial Farmer-type chamber.

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利用不同半径的法默型电离室进行磁场中的碳离子束剂量测定:测量与模拟。
目标: 研究磁场对碳离子参考场中剂量分布和电离室响应的影响,并确定不同容积电离室的磁场修正系数:研究磁场对碳离子参考场中剂量分布和电离室响应的影响,并确定不同体积电离室的磁场修正系数:使用实验电磁铁测量了六个不同半径(1 至 6 毫米,称为 R1 至 R6)的 Farmer 型电离室在高达 1 T 且增量为 0.1 T 的磁场中的响应,并与蒙特卡罗模拟进行了比较。腔室读数是在 390.75 MeV/u 的单能量碳离子束入口区域测量的。为了进行比较,对 R3 试验室采用了 200.28 MeV/u 的较低能量。对 R3 室的极性和重组修正进行了研究。通过蒙特卡洛计算了磁场引起的局部剂量变化,再结合腔室响应的变化,计算出最终的磁场校正因子:腔体响应对磁场的依赖是非线性的,且与体积有关。磁场对极性和离子重组校正没有显著影响。在 0.2 T、束能为 390.75 MeV/u 时,局部剂量的最大变化为 (0.03±0.08)%。不同腔室的磁场校正因子从 0.28% (R4) 到 0.60% (R5)不等:本研究首次使用不同半径的腔室,详细分析了腔室对高达 1 T 磁通密度的响应,并与模拟结果进行了比较。通过将室响应变化与局部剂量变化相结合,计算出了包括商用 Farmer 型室在内的所有六个室的磁场校正因子。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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