A modified withdrawal time estimation and risk assessment of enrofloxacin in grass carp (Ctenopharyngodon idella) after ad libitum medicated feed based on statistical approaches in natural cultured environments.

IF 1.8 3区 农林科学 Q2 VETERINARY SCIENCES Veterinary Research Communications Pub Date : 2024-10-01 Epub Date: 2024-07-25 DOI:10.1007/s11259-024-10475-0
Ning Xu, Huan Zhang, Jing Dong, Yibin Yang, Yongtao Liu, Shun Zhou, Xia Zhu, Xiaohui Ai
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Abstract

Enrofloxacin (EF) is a broad-spectrum and highly efficient antibiotic commonly used for treating diseases in aquatic animals. However, its abuse in aquaculture applications often leads to excess residue in tissues of grass carp (Ctenopharyngodon idella). Hence, this study aimed to estimate the withdrawal time (WT) of EF and its metabolite of ciprofloxacin (CF) administered medicated feed in natural culture environments and conduct a risk assessment. Plasma and tissue samples were gathered at appropriate time points and detected by high-performance liquid chromatography. The data homogeneity was evaluated by Bartlett's test and Cochran's test. The linearity of the regressed line was evaluated by visual inspection and F test. Outliers were estimated on a normal probability scale by plotting the standardized residual versus their cumulative frequency distribution. Finally, the WT was calculated to be 51 days in muscle + skin based on the maximum residue limit of 100 µg/kg. After 51 days, the concentration of EF and CF fell below 10 µg/kg. The estimated daily intake was calculated to be 0.009 µg/kg/d. Hazard quotient was computed to be 0.002, which was far below one. These results suggested that calculated WT of EF could ensure the safety of products from grass carp for humans.

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基于自然养殖环境中的统计方法,对草鱼(Ctenopharyngodon idella)自由采食药物饲料后恩诺沙星的停药时间估计和风险评估进行修正。
恩诺沙星(EF)是一种广谱高效抗生素,常用于治疗水生动物疾病。然而,其在水产养殖中的滥用往往会导致草鱼(Ctenopharyngodon idella)组织中的残留超标。因此,本研究旨在估算环丙沙星(CF)药物饲料中 EF 及其代谢物在自然养殖环境中的停药时间(WT),并进行风险评估。在适当的时间点采集血浆和组织样本,并采用高效液相色谱法进行检测。通过巴特利特检验和科克兰检验评估了数据的同质性。回归线的线性度通过目测和 F 检验进行评估。通过绘制标准化残差与其累积频率分布图,按照正态概率标度估算异常值。最后,根据 100 微克/千克的最大残留限量,计算出肌肉和皮肤中的 WT 为 51 天。51 天后,EF 和 CF 的浓度降至 10 微克/千克以下。经计算,估计日摄入量为 0.009 微克/千克/天。计算得出的危害商为 0.002,远远低于 1。这些结果表明,计算出的 EF WT 可确保草鱼产品对人类的安全性。
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来源期刊
Veterinary Research Communications
Veterinary Research Communications 农林科学-兽医学
CiteScore
2.50
自引率
0.00%
发文量
173
审稿时长
3 months
期刊介绍: Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial. The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.
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