Biomarkers of Orthodontic Patients After Use of 1% Brazilian Red Propolis Toothpaste: A Randomized Clinical Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-27 eCollection Date: 2024-05-01 DOI:10.4103/jispcd.jispcd_120_23

Mônica do Amaral Silva, Lídia Audrey Rocha Valadas, Guilherme Antônio Lopes de Oliveira, Edilson Martins Rodrigues Neto, Emmanuel Arraes de Alencar Júnior, Patricia Leal Dantas Lobo, Thereza Cristina Farias Botelho Dantas, Mary Anne Medeiros Bandeira, Marta Maria de França Fonteles, Gandhi Radis Baptista

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Abstract

Aim: To evaluate the salivary biomarkers and plaque index after a treatment with a propolis-contained toothpaste.

Materials and methods: This is a longitudinal, randomized, double-blind study where 76 participants were randomized into two groups: Group I: Fluoridated Red Propolis toothpaste; Group II: Fluoridated toothpaste. The participants were selected in a municipality without fluoridated public water. All participants received standardized oral hygiene instructions from the same instructor for 3 daily brushings (after breakfast, after lunch, and before bed) for a period of 2 min; Saliva samples were collected before (D0) and after 28 days (D28) of treatment for analysis of pH and total protein, amylase, and IL-10. Saliva was collected in the initial consultation and on return, totaling two collections. All samples were collected under the same conditions, by the same operator and between 9:00 AM and 11:00 AM in order to minimize the influence of circadian rhythm on salivary flow.

Results: On D0 and D28, the various treatments had no effect on total salivary proteins (G1: P = 0.0746; G2: P = 0.2144), and the pH stayed about the same. Additionally, there was no change in the amylase activity in G1 (P = 0.1877) or G2 (P = 0.4674). Significant decreases in G1 (P < 0.0001) and G2 (P = 0.03) were observed with IL-10. There was no statistically significant difference in the salivary flow between the BRP toothpaste-treated group (P = 0.172) and the commercial fluoridated toothpaste-treated group (P = 0.329). Compared to G2 (P = 0.03), G1 showed a superior decline in the plaque index (P = <0.0001).

Conclusions: After 28 days of using the toothpastes, there were no changes in the amylase, pH, or total protein indicators. After 28 days, there was a decrease in the propolis group's IL-10 dose and plaque index.

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正畸患者使用 1%巴西红蜂胶牙膏后的生物标志物：随机临床研究

目的：评估使用含蜂胶牙膏治疗后的唾液生物标志物和牙菌斑指数：这是一项纵向、随机、双盲研究，将 76 名参与者随机分为两组：第一组：含氟红蜂胶牙膏；第二组：含氟牙膏。这些参与者被选中在一个没有氟化公共水的城市。所有参与者都接受了同一指导员的标准化口腔卫生指导，每天刷牙 3 次（早餐后、午餐后和睡前），每次 2 分钟；在治疗前（D0）和治疗 28 天后（D28）采集唾液样本，分析 pH 值、总蛋白、淀粉酶和 IL-10。在初诊和复诊时采集唾液样本，共采集两次。所有样本均在相同条件下采集，由同一操作人员在上午 9:00 至 11:00 之间采集，以尽量减少昼夜节律对唾液流量的影响：在第 0 天和第 28 天，各种处理对唾液蛋白质总量没有影响（G1：P = 0.0746；G2：P = 0.2144），pH 值也基本保持不变。此外，G1（P = 0.1877）和 G2（P = 0.4674）的淀粉酶活性也没有变化。观察到 IL-10 在 G1（P < 0.0001）和 G2（P = 0.03）中的显著下降。BRP牙膏处理组（P = 0.172）和商用含氟牙膏处理组（P = 0.329）之间的唾液流量差异无统计学意义。与 G2 组相比（P = 0.03），G1 组的牙菌斑指数下降幅度更大（P = 结论：G1 组的牙菌斑指数下降幅度比 G2 组小）：使用牙膏 28 天后，淀粉酶、pH 值和总蛋白指标均无变化。28天后，蜂胶组的IL-10剂量和牙菌斑指数有所下降。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.