Proteomic investigations of dengue virus infection: key discoveries over the last 10 years.

IF 3.8 3区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS Expert Review of Proteomics Pub Date : 2024-07-01 Epub Date: 2024-07-24 DOI:10.1080/14789450.2024.2383580
Sudarat Hadpech, Visith Thongboonkerd
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Abstract

Introduction: Dengue virus (DENV) infection remains one of the most significant infectious diseases in humans. Several efforts have been made to address its molecular mechanisms. Over the last 10 years, proteomics has been widely applied to investigate various aspects of DENV infection.

Areas covered: In this review, we briefly introduce common proteomics approaches using various mass spectrometric modalities followed by summarizing all the discoveries obtained from proteomic investigations of DENV infection over the last 10 years. These include the data on DENV-vector interactions and host responses to address the DENV biology and disease mechanisms. Moreover, applications of proteomics to disease prevention, diagnosis, vaccine design, development of anti-DENV agents and other new treatment strategies are discussed.

Expert opinion: Despite efforts on disease prevention, DENV infection is still a significant global healthcare burden that affects the general population. As summarized herein, proteomic technologies with high-throughput capabilities have provided more in-depth details of protein dynamics during DENV infection. More extensive applications of proteomics and other powerful research tools would provide a promise to better cope and prevent this mosquito-borne infectious disease.

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登革热病毒感染的蛋白质组学研究:过去 10 年的重大发现。
导言:登革病毒(DENV)感染仍是人类最重要的传染病之一。人们为研究其分子机制做出了许多努力。在过去 10 年中,蛋白质组学已被广泛应用于研究登革热病毒感染的各个方面:在这篇综述中,我们简要介绍了使用各种质谱模式的常见蛋白质组学方法,然后总结了过去10年中从DENV感染的蛋白质组学研究中获得的所有发现。这些发现包括有关DENV-病媒相互作用和宿主反应的数据,以解决DENV生物学和疾病机制问题。此外,还讨论了蛋白质组学在疾病预防、诊断、疫苗设计、抗DENV制剂开发和其他新治疗策略方面的应用:尽管在疾病预防方面做出了努力,但 DENV 感染仍然是影响普通人群的一个重要的全球医疗负担。正如本文所总结的,具有高通量能力的蛋白质组学技术提供了 DENV 感染过程中蛋白质动态的更多细节。更广泛地应用蛋白质组学和其他强大的研究工具将有望更好地应对和预防这种蚊媒传染病。
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来源期刊
Expert Review of Proteomics
Expert Review of Proteomics 生物-生化研究方法
CiteScore
7.60
自引率
0.00%
发文量
20
审稿时长
6-12 weeks
期刊介绍: Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.
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