Application of Diffusion Kurtosis Imaging and Blood Oxygen Level-Dependent Magnetic Resonance Imaging in Kidney Injury Associated with ANCA-Associated Vasculitis.

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Tomography Pub Date : 2024-06-25 DOI:10.3390/tomography10070073

Wenhui Yu, Weijie Yan, Jing Yi, Lu Cheng, Peiyi Luo, Jiayu Sun, Shenju Gou, Ping Fu

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Abstract

Objective: Functional magnetic resonance imaging (fMRI) has been applied to assess the microstructure of the kidney. However, it is not clear whether fMRI could be used in the field of kidney injury in patients with Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Methods: This study included 20 patients with AAV. Diffusion kurtosis imaging (DKI) and blood oxygen level-dependent (BOLD) scanning of the kidneys were performed in AAV patients and healthy controls. The mean kurtosis (MK), mean diffusivity (MD), and fractional anisotropy (FA) parameters of DKI, the R2* parameter of BOLD, and clinical data were further analyzed.

Results: In AAV patients, the cortex exhibited lower MD but higher R2* values compared to the healthy controls. Medullary MK values were elevated in AAV patients. Renal medullary MK values showed a positive correlation with serum creatinine levels and negative correlations with hemoglobin levels and estimated glomerular filtration rate. To assess renal injury in AAV patients, AUC values for MK, MD, FA, and R2* in the cortex were 0.66, 0.67, 0.57, and 0.55, respectively, and those in the medulla were 0.81, 0.77, 0.61, and 0.53, respectively.

Conclusions: Significant differences in DKI and BOLD MRI parameters were observed between AAV patients with kidney injuries and the healthy controls. The medullary MK value in DKI may be a noninvasive marker for assessing the severity of kidney injury in AAV patients.

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弥散峰度成像和血氧水平依赖性磁共振成像在ANCA相关性血管炎肾损伤中的应用

目的功能磁共振成像（fMRI）已被用于评估肾脏的微观结构。然而，尚不清楚 fMRI 是否可用于抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）患者的肾脏损伤领域：本研究纳入了20名AAV患者。对 AAV 患者和健康对照组的肾脏进行了弥散峰度成像（DKI）和血氧水平依赖性（BOLD）扫描。对 DKI 的平均峰度（MK）、平均扩散率（MD）和分数各向异性（FA）参数、BOLD 的 R2* 参数以及临床数据进行了进一步分析：结果：与健康对照组相比，AAV 患者大脑皮层的 MD 值较低，但 R2* 值较高。AAV 患者髓质 MK 值升高。肾髓质 MK 值与血清肌酐水平呈正相关，与血红蛋白水平和估计肾小球滤过率呈负相关。为评估 AAV 患者的肾损伤，皮质的 MK、MD、FA 和 R2* 的 AUC 值分别为 0.66、0.67、0.57 和 0.55，髓质的 AUC 值分别为 0.81、0.77、0.61 和 0.53：结论：AAV肾损伤患者的DKI和BOLD MRI参数与健康对照组存在显著差异。DKI 中的髓质 MK 值可能是评估 AAV 患者肾损伤严重程度的无创标志物。

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.