Iris melanoma in an Australian cohort

IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Clinical and Experimental Ophthalmology Pub Date : 2024-07-24 DOI:10.1111/ceo.14424
Lindsay A. McGrath MPhil, FRANZCO, Sunil K. Warrier FRANZCO, William J. Glasson FRANZCO, Matthew G. D'Mellow BSc, Hayley R. Hamilton BNurs, Jane M. Palmer RN, Kelly M. Brooks PhD, Peter A. Johansson PhD, Nicholas K. Hayward PhD
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Abstract

Background

To report the clinicopathological features and epidemiology of iris melanoma in Queensland, Australia.

Methods

This was a retrospective study of 86 patients with iris melanoma treated between 2001 and 2022 at the Queensland Ocular Oncology Service, Brisbane, Australia. Main outcome measures included demographics, clinical and phenotypic features, age-adjusted incidence and relative survival.

Results

Eighty-six patients (63% female) were included. Mean age was 54 years (range 17–82 years). The majority of patients (97%) were Caucasian, with blue eyes, fair skin and Fitzpatrick Skin Type I or II. Demographic features and clinical history showed a tendency for high ultraviolet radiation (UVR) exposure in the cohort. Histopathology was available in 69 cases (82%), and of these, 77% tumours were of spindle cell origin, with low-risk genetic profiles. Patients were followed for a mean of 8 years (median 7, range 1–21 years) after diagnosis, and only one case of metastasis was documented.

Conclusions

The association of iris freckles, history of UVR exposure and dermatologic findings supports the role of UVR in iris melanoma. Occupation and avocation history, as well as evaluation of iris freckles may offer an easily accessible way of stratifying the risk of an individual for development of UVR-related uveal melanoma.

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澳大利亚队列中的虹膜黑色素瘤。
背景:报告澳大利亚昆士兰州虹膜黑色素瘤的临床病理特征和流行病学:报告澳大利亚昆士兰州虹膜黑色素瘤的临床病理特征和流行病学:这是一项回顾性研究,研究对象是2001年至2022年期间在澳大利亚布里斯班昆士兰眼肿瘤学服务机构接受治疗的86名虹膜黑色素瘤患者。主要结果指标包括人口统计学、临床和表型特征、年龄调整后发病率和相对生存率:共纳入 86 名患者(63% 为女性)。平均年龄为 54 岁(17-82 岁不等)。大多数患者(97%)为白种人,蓝眼睛,皮肤白皙,菲茨帕特里克皮肤类型 I 型或 II 型。人口统计学特征和临床病史显示,该组患者有紫外线辐射(UVR)暴露较高的倾向。69例患者(82%)获得了组织病理学检查结果,其中77%的肿瘤为纺锤形细胞来源,遗传特征风险较低。患者在确诊后平均随访了8年(中位数为7年,范围为1-21年),仅有一例转移病例记录在案:结论:虹膜雀斑、紫外线照射史和皮肤病学检查结果都支持紫外线照射在虹膜黑色素瘤中的作用。职业和职业史以及对虹膜雀斑的评估可提供一种简便易行的方法,用于对个人罹患紫外线相关葡萄膜黑色素瘤的风险进行分层。
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来源期刊
CiteScore
7.60
自引率
12.50%
发文量
150
审稿时长
4-8 weeks
期刊介绍: Clinical & Experimental Ophthalmology is the official journal of The Royal Australian and New Zealand College of Ophthalmologists. The journal publishes peer-reviewed original research and reviews dealing with all aspects of clinical practice and research which are international in scope and application. CEO recognises the importance of collaborative research and welcomes papers that have a direct influence on ophthalmic practice but are not unique to ophthalmology.
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