Sex-related patterns of functional brain networks in children and adolescents with autism spectrum disorder

IF 5.3 2区 医学 Q1 BEHAVIORAL SCIENCES Autism Research Pub Date : 2024-07-25 DOI:10.1002/aur.3180
Cuicui Li, Jingxuan Wang, Yunna Zhou, Tong Li, Baolin Wu, Xianshun Yuan, Lin Li, Rui Qin, Hongzhu Liu, Linglong Chen, Ximing Wang
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Abstract

Although numerous studies have emphasized the male predominance in autism spectrum disorder (ASD), how sex differences are related to the topological organization of functional networks remains unclear. This study utilized imaging data from 86 ASD (43 females, aged 7–18 years) and 86 typically developing controls (TCs) (43 females, aged 7–18 years) obtained from Autism Brain Imaging Data Exchange databases, constructed individual whole-brain functional networks, used a graph theory analysis to compute topological metrics, and assessed sex-related differences in topological metrics using a 2 × 2 factorial design. At the global level, females with ASD exhibited significantly higher cluster coefficient and local efficiency than female TCs, while no significant difference was observed between males with ASD and male TCs. Meanwhile, the neurotypical sex differences in cluster coefficient and local efficiency observed in TCs were not present in ASD. At the nodal level, ASD exhibited abnormal nodal centrality in the left middle temporal gyrus.

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自闭症谱系障碍儿童和青少年大脑功能网络的性别相关模式。
尽管许多研究都强调自闭症谱系障碍(ASD)患者中男性居多,但性别差异与功能网络拓扑组织的关系仍不清楚。本研究利用从自闭症脑成像数据交换数据库中获得的86名自闭症谱系障碍患者(43名女性,7-18岁)和86名发育典型对照组患者(43名女性,7-18岁)的成像数据,构建了个体全脑功能网络,使用图论分析计算拓扑指标,并采用2 × 2因子设计评估了拓扑指标的性别差异。在全局水平上,女性ASD患者的聚类系数和局部效率明显高于女性TC患者,而男性ASD患者和男性TC患者之间则无明显差异。同时,在TCs中观察到的聚类系数和局部效率的神经典型性别差异在ASD中并不存在。在节点水平上,ASD 在左侧颞中回表现出异常的节点中心性。
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来源期刊
Autism Research
Autism Research 医学-行为科学
CiteScore
8.00
自引率
8.50%
发文量
187
审稿时长
>12 weeks
期刊介绍: AUTISM RESEARCH will cover the developmental disorders known as Pervasive Developmental Disorders (or autism spectrum disorders – ASDs). The Journal focuses on basic genetic, neurobiological and psychological mechanisms and how these influence developmental processes in ASDs.
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