MRI assessment of adipose tissue fatty acid composition in the UK Biobank and its association with diet and disease

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2024-07-25 DOI:10.1002/oby.24108

Marjola Thanaj, Nicolas Basty, Brandon Whitcher, Jimmy D. Bell, E. Louise Thomas

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Abstract

Objective

This study aimed to assess the fatty acid (FA) composition of abdominal subcutaneous and visceral adipose tissue (ASAT and VAT, respectively) in the UK Biobank imaging cohort (N = 33,823) using magnetic resonance imaging (MRI).

Methods

We measured the fractions of saturated, monounsaturated, and polyunsaturated FA (fSFA, fMUFA, and fPUFA, respectively) in ASAT and VAT from multiecho MRI scans. We selected a subcohort of participants who followed a vegan and an omnivore diet (N = 36) to validate the effect of diet on adipose tissue. In the wider imaging cohort, we examined the relationships between adipose tissue FA composition and various traits related to disease and body size.

Results

We measured adipose tissue FA composition for over 33,000 participants, revealing higher fSFA and fPUFA and lower fMUFA in VAT (p < 0.00016). fMUFA and fPUFA were higher in ASAT and lower in VAT for women (p < 0.00016). Vegan participants exhibited lower fSFA in both ASAT and VAT (p < 0.00016). VAT fSFA and fMUFA showed significant associations with disease, as well as anthropometric variables.

Conclusions

This extensive analysis revealed the relationships between adipose tissue FA composition and a range of factors in a diverse population, highlighting the importance of studying body adipose tissue beyond its quantity.

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英国生物库中脂肪组织脂肪酸组成的核磁共振成像评估及其与饮食和疾病的关系。

研究目的本研究旨在利用磁共振成像（MRI）评估英国生物库成像队列（N = 33,823）中腹部皮下和内脏脂肪组织（分别为 ASAT 和 VAT）的脂肪酸（FA）组成：我们通过多回波核磁共振成像扫描测量了ASAT和VAT中饱和脂肪酸、单不饱和脂肪酸和多不饱和脂肪酸的比例（分别为fSFA、fMUFA和fPUFA）。我们选择了素食者和杂食者（36 人）作为亚群，以验证饮食对脂肪组织的影响。在更广泛的成像队列中，我们研究了脂肪组织FA组成与疾病和体型相关的各种特征之间的关系：我们测量了 33,000 多名参与者的脂肪组织脂肪酸组成，结果显示，脂肪增值纤维中的 fSFA 和 fPUFA 含量较高，而 fMUFA 含量较低（p 结论：脂肪增值纤维中的 fSFA 和 fPUFA 含量较高，而 fMUFA 含量较低）：这项广泛的分析揭示了不同人群中脂肪组织脂肪酸组成与一系列因素之间的关系，突出了研究人体脂肪组织数量之外的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.