Pt nanoshells with a high NIR-II photothermal conversion efficiency mediates multimodal neuromodulation against ventricular arrhythmias

IF 14.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2024-07-28 DOI:10.1038/s41467-024-50557-w

Chenlu Wang, Liping Zhou, Chengzhe Liu, Jiaming Qiao, Xinrui Han, Luyang Wang, Yaxi Liu, Bi Xu, Qinfang Qiu, Zizhuo Zhang, Jiale Wang, Xiaoya Zhou, Mengqi Zeng, Lilei Yu, Lei Fu

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Abstract

Autonomic nervous system disorders play a pivotal role in the pathophysiology of cardiovascular diseases. Regulating it is essential for preventing and treating acute ventricular arrhythmias (VAs). Photothermal neuromodulation is a nonimplanted technique, but the response temperature ranges of transient receptor potential vanilloid 1 (TRPV1) and TWIK-related K⁺ Channel 1 (TREK1) exhibit differences while being closely aligned, and the acute nature of VAs require that it must be rapid and precise. However, the low photothermal conversion efficiency (PCE) still poses limitations in achieving rapid and precise treatment. Here, we achieve a nearly perfect blackbody absorption and a high PCE in the second near infrared (NIR-II) window (73.7% at 1064 nm) via a Pt nanoparticle shell (PtNP-shell). By precisely manipulating the photothermal effect, we successfully achieve rapid and precise multimodal neuromodulation encompassing neural activation (41.0–42.9 °C) and inhibition (45.0–46.9 °C) in a male canine model. The NIR-II photothermal modulation additionally achieves multimodal reversible autonomic modulation and confers protection against acute VAs associated with myocardial ischemia and reperfusion injury in interventional therapy.

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具有高近红外-II 光热转换效率的铂纳米壳介导多模式神经调控，防治室性心律失常

自主神经系统紊乱在心血管疾病的病理生理学中起着举足轻重的作用。调节自律神经对预防和治疗急性室性心律失常（VAs）至关重要。光热神经调控是一种非植入性技术，但瞬时受体电位类香草素 1（TRPV1）和 TWIK 相关 K+ 通道 1（TREK1）的反应温度范围在密切相关的同时也存在差异，而急性室性心律失常的急性特性要求其必须快速而精确。然而，较低的光热转换效率（PCE）仍对实现快速精确治疗造成了限制。在这里，我们通过铂纳米粒子壳（PtNP-shell）在第二个近红外（NIR-II）窗口实现了近乎完美的黑体吸收和较高的 PCE（在 1064 纳米波长处为 73.7%）。通过精确操纵光热效应，我们成功地在雄性犬模型中实现了快速、精确的多模式神经调控，包括神经激活（41.0-42.9 °C）和神经抑制（45.0-46.9 °C）。近红外-II光热调制还能实现多模式可逆自律神经调制，并在介入治疗中对心肌缺血和再灌注损伤相关的急性VA提供保护。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.