Efficient one-pot synthesis of 3-arylmethyl indoles promoted by (Bu3Sn)2MoO4 as a reusable catalyst

Abstract

An efficient multi-component protocol for synthesizing substituted 3-arylmethyl indoles derivatives through a three-component strategy using water: ethanol (H₂O:EtOH) at 45–50°C with good to excellent yields. The main advantages of this protocol are mild reaction conditions, easy workup, and recyclability of the catalyst for up to four catalytic cycles.

Graphical abstract

Synopsis: Synthesis of substituted 3-arylmethyl indoles by using efficient multi-component strategy in ethanol: water as a solvent system by using (Bu₃Sn)₂MoO₄ as a reusable catalyst at 45–50 °C with good to excellent yields. The catalyst is reusable in four catalytic cycles.