{"title":"Complementarity between Brillouin signature and Scholte wave for controlled elasticity in fibrillated collagen medium for culture cell","authors":"A. Hamraoui, O. Sénépart, L. Belliard","doi":"10.1063/5.0225336","DOIUrl":null,"url":null,"abstract":"Modulating extracellular matrix (ECM) elasticity with fibrillar collagen offers great potential for regenerative medicine, drug discovery, and disease modeling by replicating in vivo mechanical signals. This enhances the understanding of cellular responses and fosters therapeutic innovation. However, precise ECM elasticity measurements are still lacking. This study couples time-resolved Brillouin spectroscopy and pulsed laser-induced Scholte wave generation. We measure how collagen fibrillation affects sound velocity and refractive index. These insights are advancing tissue engineering and cellular biomechanics.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"APL Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1063/5.0225336","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Modulating extracellular matrix (ECM) elasticity with fibrillar collagen offers great potential for regenerative medicine, drug discovery, and disease modeling by replicating in vivo mechanical signals. This enhances the understanding of cellular responses and fosters therapeutic innovation. However, precise ECM elasticity measurements are still lacking. This study couples time-resolved Brillouin spectroscopy and pulsed laser-induced Scholte wave generation. We measure how collagen fibrillation affects sound velocity and refractive index. These insights are advancing tissue engineering and cellular biomechanics.
期刊介绍：
APL Materials features original, experimental research on significant topical issues within the field of materials science. In order to highlight research at the forefront of materials science, emphasis is given to the quality and timeliness of the work. The journal considers theory or calculation when the work is particularly timely and relevant to applications.
In addition to regular articles, the journal also publishes Special Topics, which report on cutting-edge areas in materials science, such as Perovskite Solar Cells, 2D Materials, and Beyond Lithium Ion Batteries.
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