Exploring the Role of Target Expression in Treatment Efficacy of Antibody–Drug Conjugates (ADCs) in Solid Cancers: A Comprehensive Review

IF 4.7 2区医学 Q1 ONCOLOGY Current Oncology Reports Pub Date : 2024-07-27 DOI:10.1007/s11912-024-01576-9

Laurent Mathiot, Capucine Baldini, Octave Letissier, Antoine Hollebecque, Rastislav Bahleda, Anas Gazzah, Cristina Smolenschi, Madona Sakkal, François-Xavier Danlos, Clémence Henon, Kristi Beshiri, Vincent Goldschmidt, Claudia Parisi, Anna Patrikidou, Jean-Marie Michot, Aurélien Marabelle, Sophie Postel-Vinay, Alice Bernard-Tessier, Yohann Loriot, Santiago Ponce, Stéphane Champiat, Kaïssa Ouali

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Abstract

Purpose of Review

Antibody–drug conjugates (ADCs) offer a promising path for cancer therapy, leveraging the specificity of monoclonal antibodies and the cytotoxicity of linked drugs. The success of ADCs hinges on precise targeting of cancer cells based on protein expression levels. This review explores the relationship between target protein expression and ADC efficacy in solid tumours, focusing on results of clinical trials conducted between January 2019 and May 2023.

Recent Findings

We hereby highlight approved ADCs, revealing their effectiveness even in low-expressing target populations. Assessing target expression poses challenges, owing to variations in scoring systems and biopsy types. Emerging methods, like digital image analysis, aim to standardize assessment. The complexity of ADC pharmacokinetics, tumour dynamics, and off-target effects emphasises the need for a balanced approach.

Summary

This review underscores the importance of understanding target protein dynamics and promoting standardized evaluation methods in shaping the future of ADC-based cancer therapies.

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探索靶点表达在抗体药物结合物 (ADC) 治疗实体癌疗效中的作用：全面综述

综述目的抗体-药物共轭物（ADC）利用单克隆抗体的特异性和连接药物的细胞毒性，为癌症治疗提供了一条前景广阔的途径。ADC 的成功取决于根据蛋白质表达水平对癌细胞进行精确靶向。本综述探讨了实体瘤中靶蛋白表达与ADC疗效之间的关系，重点关注2019年1月至2023年5月期间开展的临床试验结果。近期发现我们在此重点介绍已获批准的ADCs，揭示它们即使在低表达靶细胞群中也能发挥疗效。由于评分系统和活检类型的不同，评估靶点表达是一项挑战。数字图像分析等新兴方法旨在使评估标准化。本综述强调了了解靶蛋白动态和推广标准化评估方法对塑造未来基于 ADC 的癌症疗法的重要性。

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来源期刊

Current Oncology Reports ONCOLOGY-

CiteScore

8.50

自引率

0.00%

发文量

187

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.