Recurrence after primary salivary gland carcinoma: Frequency, survival, and risk factors

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-07-27 DOI:10.1002/hed.27880

Lisa Nachtsheim MD, L. Jansen, S. Shabli MD, C. Arolt MD, A. Quaas MD, J. P. Klussmann MD, M. Mayer MD, P. Wolber MD

{"title":"Recurrence after primary salivary gland carcinoma: Frequency, survival, and risk factors","authors":"Lisa Nachtsheim MD, L. Jansen, S. Shabli MD, C. Arolt MD, A. Quaas MD, J. P. Klussmann MD, M. Mayer MD, P. Wolber MD","doi":"10.1002/hed.27880","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Primary salivary gland carcinomas (SGC) are rare neoplasms that present therapeutic challenges especially in recurrent tumors. The aim of this study was to investigate the incidence and distribution of tumor recurrence, associated risk factors, and survival.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This analysis includes data from 318 patients treated for SGC between 1992 and 2020. Survival analysis was performed using the Kaplan–Meier method. Univariate and multivariate analyses were used to identify risk factors associated with recurrence.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>21.7% of the patients developed recurrent disease after a mean of 38.2 months. In multivariate analysis, positive-resection margins, vascular invasion, and tumor localization in the submandibular gland and small salivary glands were independent factors for recurrence. The 5-year overall survival was 67%, the 5-year disease-free survival was 54%.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Tumor recurrence in SGC occurred in one out of five patients. In highly aggressive entities and patients with risk factors, treatment intensification should be considered.</p>\n </section>\n </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 1","pages":"47-56"},"PeriodicalIF":2.2000,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.27880","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hed.27880","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Primary salivary gland carcinomas (SGC) are rare neoplasms that present therapeutic challenges especially in recurrent tumors. The aim of this study was to investigate the incidence and distribution of tumor recurrence, associated risk factors, and survival.

Methods

This analysis includes data from 318 patients treated for SGC between 1992 and 2020. Survival analysis was performed using the Kaplan–Meier method. Univariate and multivariate analyses were used to identify risk factors associated with recurrence.

Results

21.7% of the patients developed recurrent disease after a mean of 38.2 months. In multivariate analysis, positive-resection margins, vascular invasion, and tumor localization in the submandibular gland and small salivary glands were independent factors for recurrence. The 5-year overall survival was 67%, the 5-year disease-free survival was 54%.

Conclusion

Tumor recurrence in SGC occurred in one out of five patients. In highly aggressive entities and patients with risk factors, treatment intensification should be considered.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

原发性唾液腺癌术后复发：频率、存活率和风险因素

背景原发性唾液腺癌（SGC）是一种罕见肿瘤，给治疗带来了挑战，尤其是复发性肿瘤。本研究旨在调查肿瘤复发的发生率和分布情况、相关风险因素以及生存率。采用卡普兰-梅耶法进行生存率分析。结果21.7%的患者在平均38.2个月后复发。在多变量分析中，切除边缘阳性、血管侵犯、肿瘤位于颌下腺和小唾液腺是导致复发的独立因素。5年总生存率为67%，5年无病生存率为54%。对于侵袭性强的肿瘤和有危险因素的患者，应考虑加强治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.