The expression and biological role of complement C1s in esophageal squamous cell carcinoma

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-24 DOI:10.1515/biol-2022-0915

Ruomu Ge, Zhengyun Luan, Ting Guo, Sheng Xia, Jun Ye, Jie Xu

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Abstract

The present work focused on investigating the role of the altered expression of complement C1s in proliferation and apoptosis of esophageal squamous cell carcinoma (ESCC) cells and explore its biological functions in ESCC, so as to lay a theoretical foundation and provide certain clinical reference for diagnosing and treating ESCC. Complement C1s expression within ESCC was assessed, and its clinical pathological characteristics in ESCC patients were analyzed. Subsequently, in vitro experiments were performed to further explore the mechanisms by which complement C1s affected ESCC. According to the results, complement C1s expression within ESCC markedly increased relative to adjacent non-cancerous samples. High C1s expression showed positive relation to race, residual lesion, and tumor location of ESCC patients. Complement C1s affected ESCC cell proliferation and apoptosis. Notably, C1s knockdown significantly inhibited ESCC cell proliferation and enhanced their apoptosis. C1s suppressed ESCC cell proliferation via Wnt1/β-catenin pathway and promoted their apoptosis through modulating the expression of Bcl2, Bax, and cleaved-caspase3.

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补体 C1s 在食管鳞状细胞癌中的表达和生物学作用

本研究主要探讨补体C1s表达的改变在食管鳞状细胞癌（ESCC）细胞增殖和凋亡中的作用，并探索其在ESCC中的生物学功能，从而为诊断和治疗ESCC奠定理论基础并提供一定的临床参考。本研究评估了补体C1s在ESCC中的表达，并分析了其在ESCC患者中的临床病理特征。随后，通过体外实验进一步探讨了补体C1s对ESCC的影响机制。结果显示，与邻近的非癌样本相比，补体C1s在ESCC中的表达明显增加。补体C1s的高表达与ESCC患者的种族、残留病灶和肿瘤位置呈正相关。补体C1s影响ESCC细胞的增殖和凋亡。值得注意的是，C1s基因敲除能显著抑制ESCC细胞的增殖并增强其凋亡。C1s通过Wnt1/β-catenin通路抑制ESCC细胞增殖，并通过调节Bcl2、Bax和裂解-caspase3的表达促进其凋亡。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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