Xinze Liu, Kaijing Sun, Lin Feng, Xin Jin, Ying Sun, Wei Wu, Changbao Chen, Xilin Wan
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引用次数: 0
Abstract
Colon cancer is a malignant tumor caused by a malignant lesion of the colonic mucosal epithelium, with a high incidence in recent years. Fungi substances contain polysaccharides, terpenes, flavonoids and other chemical components, and the diversity of chemical components determines the strength of its biological activity. Studies have shown that the chemical components in fungi can be used as drugs to inhibit the growth of colon cancer. All available information about the bioactivities and mechanisms of fungus extracts and compounds in colon cancer was supplied by library database and electronic search (PubMed, ScienceDirect, CNKI, Web of Science, Google Scholar, etc.). Fungi reflect significant anti colon cancer effects through effects on colon cancer cell proliferation, cell cycle, apoptosis, tumor growth and protein expression. At present, most research focus on colon cancer cells and animal models. This review is on the purpose of the inhibition effects of chemical components in fungi on colon cancer at two levels in vivo and in vitro were reviewed. All the studies demonstrated significant improvements in colorectal cancer cells and animals after the fungi substances interventions. In this review, we give a complete overview of this subject, and summarizes recent research findings about molecular mechanisms on anti colorectal cancer.
结肠癌是结肠粘膜上皮恶性病变引起的恶性肿瘤,近年来发病率较高。真菌物质中含有多糖、萜类、黄酮类等化学成分,化学成分的多样性决定了其生物活性的强弱。研究表明,真菌中的化学成分可以作为抑制结肠癌生长的药物。通过图书馆数据库和电子检索(PubMed、ScienceDirect、CNKI、Web of Science、Google Scholar 等),获得了关于真菌提取物和化合物在结肠癌中的生物活性和机制的所有可用信息。真菌通过对结肠癌细胞增殖、细胞周期、细胞凋亡、肿瘤生长和蛋白质表达的影响,体现出明显的抗结肠癌作用。目前,大多数研究都集中在结肠癌细胞和动物模型上。本综述从体内和体外两个层面综述了真菌中的化学成分对结肠癌的抑制作用。所有研究都表明,在真菌物质干预后,结直肠癌细胞和动物的情况都有明显改善。在这篇综述中,我们对这一主题进行了全面概述,并总结了有关抗结直肠癌分子机制的最新研究成果。
期刊介绍:
Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource.
Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.