Platinum Nanoparticles in Aqueous Solutions of a Chitosan–Vinylpyrrolidone Copolymer: Synthesis and Biological Activity

IF 1 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Applied Biochemistry and Microbiology Pub Date : 2024-07-27 DOI:10.1134/S0003683824604451

D. N. Zuev, E. I. Cherkasova, K. V. Apryatina, S. D. Zaitsev, L. A. Smirnova

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Abstract

Grafted copolymers of chitosan–vinylpyrrolidone, water-soluble at a pH of 6.8–7.5, were obtained. A technique has been developed for obtaining an aggregatively stable system of platinum nanoparticles in copolymer solutions with an average size of ~4 nm. The thermophysical and structural characteristics of the powdered composition of a platinum nanoparticle-copolymer are investigated. An in vitro comparison of the antitumor activity of solutions of the developed composition and cisplatin at the same platinum concentration was performed. It was found that with respect to the culture of HeLa Kyoto and A431 cancer cells, the composition is five and two times less effective than cisplatin, respectively. Along with this, the biocompatibility of the composition is 17 times higher than that of cisplatin, which allows its use at elevated concentrations and the development of an antitumor agent with platinum nanoparticles commensurate in effectiveness with cisplatin.

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壳聚糖-乙烯基吡咯烷酮共聚物水溶液中的铂纳米粒子：合成与生物活性

摘要获得了壳聚糖-乙烯基吡咯烷酮接枝共聚物，在 pH 值为 6.8-7.5 时可溶于水。已开发出一种技术，可在共聚物溶液中获得平均粒径约为 4 纳米的聚集稳定的铂纳米粒子系统。研究了铂纳米粒子-共聚物粉末成分的热物理和结构特征。在体外比较了所开发组合物溶液和顺铂在相同铂浓度下的抗肿瘤活性。结果发现，在培养 HeLa Kyoto 和 A431 癌细胞时，该组合物的效果分别是顺铂的 5 倍和 2 倍。此外，该组合物的生物相容性比顺铂高 17 倍，因此可以在较高浓度下使用，并开发出一种铂纳米粒子抗肿瘤剂，其效果与顺铂相当。

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来源期刊

Applied Biochemistry and Microbiology 生物-生物工程与应用微生物

CiteScore

1.70

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.