Association between chemokine genes polymorphisms and susceptibility to Parkinson’s disease: a meta-analysis and systematic review

IF 2 4区医学 Q3 CLINICAL NEUROLOGY Acta neurologica Belgica Pub Date : 2024-07-27 DOI:10.1007/s13760-024-02615-9

Young Ho Lee, Gwan Gyu Song

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Abstract

Objective

This study aimed to investigate the potential association between polymorphisms in monocyte chemoattractant protein-1 (MCP-1), chemokine receptor type 2 (CCR2), type 5 (CCR5), regulated on activation, normal T cell expressed, and secreted (RANTES) and susceptibility to Parkinson’s disease (PD).

Methods

The MEDLINE, EMBASE, and Web of Science databases were searched for relevant articles, and a meta-analysis was conducted to assess the associations between the MCP-1 -2518 G/A, CCR2 V64I, CCR5-Δ32, RANTES − 405 G/A, -28 G/A polymorphisms and the risk of PD.

Results

Six studies with 1,416 patients with PD and 1,715 controls that met the inclusion criteria were identified. Meta-analysis of all study participants demonstrated no association between PD and the MCP-1 -2518 G allele (odds ratio [OR] = 1.089, 95% confidence interval [CI] = 0.980–1.211, p = 0.114). Stratification by ethnicity indicated no association between the MCP-1 -2518 G allele and PD in the European and Asian populations. Meta-analysis demonstrated no association between PD and the MCP-1-2518 A/G polymorphism in recessive and dominant models and homozygote contrast. However, meta-analysis revealed a significant association between the risk of PD and the CCR2-V64I AA + GG genotype in all study participants (OR = 0.418, 95% CI = 0.232–0.753, p = 0.004). Stratification based on ethnicity validated this association between the CCR2-V64I AA + GG genotype and PD in the Asian population (OR = 0.460, 95% CI = 0.243–0.870, p = 0.017), but not in European populations. Analysis using the homozygous contrast model revealed the same pattern for the CCR2-V64I AA + GG genotype. Meta-analysis revealed no association between the CCR5-Δ32 allele and the risk of PD (OR = 0.972, 95% CI = 0.377–2.501, p = 0.952). Moreover, the meta-analysis demonstrated no allelic association between RANTES − 405 G/A and − 28 G/A polymorphisms and the risk of PD.

Conclusions

Our meta-analysis showed that the CCR2 V64I polymorphism is associated with PD, especially in Asian populations.

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趋化因子基因多态性与帕金森病易感性之间的关系：荟萃分析和系统综述

目的本研究旨在探讨单核细胞趋化蛋白-1（MCP-1）、2型趋化因子受体（CCR2）、5型趋化因子受体（CCR5）、活化调节、正常T细胞表达和分泌（RANTES）的多态性与帕金森病（PD）易感性之间的潜在关联。方法在MEDLINE、EMBASE和Web of Science数据库中检索相关文章，并进行荟萃分析，以评估MCP-1 -2518 G/A、CCR2 V64I、CCR5-Δ32、RANTES - 405 G/A、-28 G/A多态性与帕金森病风险之间的关联。对所有研究参与者进行的 Meta 分析表明，PD 与 MCP-1 -2518 G 等位基因之间没有关联（几率比 [OR] = 1.089，95% 置信区间 [CI] = 0.980-1.211，P = 0.114）。按种族分层表明，在欧洲和亚洲人群中，MCP-1 -2518 G 等位基因与帕金森病之间没有关联。荟萃分析表明，在隐性和显性模型以及同基因对比中，帕金森病与 MCP-1-2518 A/G 多态性之间没有关联。然而，荟萃分析显示，在所有研究参与者中，PD 风险与 CCR2-V64I AA + GG 基因型之间存在显著关联（OR = 0.418，95% CI = 0.232-0.753，p = 0.004）。在亚洲人群中，基于种族的分层验证了 CCR2-V64I AA + GG 基因型与帕金森病之间的关联（OR = 0.460，95% CI = 0.243-0.870，p = 0.017），但在欧洲人群中却没有验证。使用同型对比模型进行的分析表明，CCR2-V64I AA + GG 基因型也具有相同的模式。荟萃分析显示，CCR5-Δ32等位基因与罹患帕金森病的风险之间没有关联（OR = 0.972，95% CI = 0.377-2.501，p = 0.952）。此外，荟萃分析表明，RANTES - 405 G/A 和 - 28 G/A 多态性与罹患帕金森病的风险没有等位关系。

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来源期刊

Acta neurologica Belgica 医学-临床神经学

CiteScore

4.20

自引率

3.70%

发文量

300

审稿时长

6-12 weeks

期刊介绍： Peer-reviewed and published quarterly, Acta Neurologica Belgicapresents original articles in the clinical and basic neurosciences, and also reports the proceedings and the abstracts of the scientific meetings of the different partner societies. The contents include commentaries, editorials, review articles, case reports, neuro-images of interest, book reviews and letters to the editor. Acta Neurologica Belgica is the official journal of the following national societies: Belgian Neurological Society Belgian Society for Neuroscience Belgian Society of Clinical Neurophysiology Belgian Pediatric Neurology Society Belgian Study Group of Multiple Sclerosis Belgian Stroke Council Belgian Headache Society Belgian Study Group of Neuropathology