Recent advances in post-chiroptical manipulation of supramolecular aggregates assembled with molecular modules

Abstract

Recently, various supramolecular assembly systems have been identified where the pre-existing chiral supramolecular structure can be manipulated through environmental adjustments, such as temperature, solvent, and concentration. These changes result in diverse microscopic morphologies during the assembly process and induce chiroptical variations, particularly in circular di-chroism (CD) and circularly polarized luminescence (CPL) spectra. These chiroptical properties serve as direct indicators of the chiral supramolecular structure and hold promise for applications in sensing, molecular recognition, asymmetric synthesis, and material science. This review focuses on research published in the last five years, highlighting instances where assembled structures aggregated by small organic molecular modules demonstrate in-situ chiroptical changes through external condition control. It categorizes and discusses different modes of regulation, aiming to offer insights and guidelines for exploring dynamic changes in assembly processes and designing in-situ adjustable structures of assembly modules.