Aerodynamic thermal breakup droplet ionization combined with a β-irradiation source for mass-spectrometric analysis of samples in a nonpolar solvent

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL Talanta Pub Date : 2024-07-25 DOI:10.1016/j.talanta.2024.126573

引用次数: 0

Abstract

A method is proposed for increasing the number of ions during mass-spectrometric analysis of samples in a nonpolar solvent (benzene). For this purpose, aerodynamic thermal breakup droplet ionization (ATBDI) with the impact of β-radiation on the aerosol droplets used in ATBDI was evaluated. This modification of the method, which we named β-ATBDI, allows to shift a nonvolatile analyte (trinitrotoluene in the negative ionization region and cocaine in the positive ionization region, as an example) into a gas phase as an aerosol at room temperature (in contrast to atmospheric pressure chemical ionization). In addition, β-ATBDI enables a researcher to distinguish mass spectrometric peaks of the compounds located in an aerosol droplet from compounds located outside the droplet, i.e., to identify background peaks. Also briefly discussed the ionization of two antibiotics—azithromycin in methylene chloride and sulfadiazine in salt water with β-ATBDI, ATBDI and electrospray ionization source.

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空气动力热破裂液滴电离与β-辐照源相结合，用于非极性溶剂中样品的质谱分析。

提出了一种在非极性溶剂（苯）中对样品进行质谱分析时增加离子数量的方法。为此，我们评估了空气动力热破裂液滴离子化（ATBDI）方法，以及 β 辐射对 ATBDI 所用气溶胶液滴的影响。我们将这种方法命名为 β-ATBDI，它可以在室温下将非挥发性分析物（例如负电离区的三硝基甲苯和正电离区的可卡因）以气溶胶的形式转移到气相中（与常压化学电离不同）。此外，β-ATBDI 使研究人员能够区分气溶胶液滴中的化合物质谱峰和液滴外的化合物质谱峰，即识别背景峰。还简要讨论了利用 β-ATBDI、ATBDI 和电喷雾离子源电离两种抗生素--二氯甲烷中的阿奇霉素和盐水中的磺胺嘧啶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.