Skeletal muscle hypertrophy: cell growth is cell growth.

IF 5 2区 生物学 Q2 CELL BIOLOGY American journal of physiology. Cell physiology Pub Date : 2024-09-01 Epub Date: 2024-07-29 DOI:10.1152/ajpcell.00418.2024
Benjamin I Burke, Ahmed Ismaeel, Ferdinand von Walden, Kevin A Murach, John J McCarthy
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Abstract

Roberts et al. have provided an insightful counterpoint to our review article on the utility of the synergist ablation model. The purpose of this review is to provide some further dialogue regarding the strengths and weaknesses of the synergist ablation model. Specifically, we highlight that the robustness of the model overshadows surgical limitations. We also compare the transcriptomic responses to synergist ablation in mice and resistance exercise in humans to identify common pathways. We conclude that "cell growth is cell growth" and that the mechanisms available to cells to accumulate biomass and increase in size are similar across cell types and independent of the rate of growth.

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回应反驳啮齿动物增效剂消融模型在确定骨骼肌肥大的分子和细胞机制方面的实用性。
罗伯茨等人对我们关于协同消融模式的实用性的评论文章提出了有见地的反驳。这篇综述的目的是就协同消融模式的优缺点提供一些进一步的对话。具体来说,我们强调该模型的稳健性掩盖了手术的局限性。我们还比较了小鼠对增效剂消融和人类阻力运动的转录组反应,以确定共同的途径。我们的结论是:"细胞生长就是细胞生长",细胞积累生物量和增大体积的机制在不同类型的细胞中是相似的,与生长速度无关。
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来源期刊
CiteScore
9.10
自引率
1.80%
发文量
252
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly. Manuscripts dealing with the structure and function of cell membranes, contractile systems, cellular organelles, and membrane channels, transporters, and pumps are encouraged. Studies dealing with integrated regulation of cellular function, including mechanisms of signal transduction, development, gene expression, cell-to-cell interactions, and the cell physiology of pathophysiological states, are also eagerly sought. Interdisciplinary studies that apply the approaches of biochemistry, biophysics, molecular biology, morphology, and immunology to the determination of new principles in cell physiology are especially welcome.
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