Close relationship with the glandular capsule:a highly sensitive diagnostic indicator of major salivary gland metastatic malignancies in ultrasound.

IF 2.9 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Dento maxillo facial radiology Pub Date : 2024-07-27 DOI:10.1093/dmfr/twae041
Huan-Zhong Su, Yan-Ting Lin, Shu-Jing Huang, Yu-Qing Su, Qi-Xia Liu, Dong-Yu Bai, Long-Cheng Hong, Xiao-Dong Zhang, Yi-Ming Su
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Abstract

Objectives: To investigate the ultrasound (US) characteristics of metastatic malignancies (MM) in the major salivary glands and to assess the diagnostic value of the close relationship with the glandular capsule in identifying MM.

Methods: From January 2016 and April 2022, 122 patients with major salivary gland malignancies, including 20 patients with MM and 102 patients with primary malignancies (PM) confirmed by histopathological examination, were enrolled in this study. Their clinicopathologic and US data were recorded and analyzed. The diagnostic performance of the close relationship with the glandular capsule for differentiating MM from PM was analyzed.

Results: The mean age of MM were older than that of PM (59.50 ± 14.57 vs. 49.96 ± 15.73, p = 0.013). Compared with PM patients, MM were associated with a higher prevalence of local pain symptoms (p = 0.007) and abnormal facial nerve function (p < 0.001). MM were also more frequently characterized by unclear borders, rough margins, irregular shapes, heterogeneous internal echos, absence of cystic areas, presence of calcifications, close relationship with the glandular capsule, and US-reported positive cervical lymph nodes (all p < 0.05). The close relationship with the glandular capsule showed to be a good indicator in distinguishing between MM and PM, with an area under the receiver operating characteristic curve of 0.863, a sensitivity of 100%, a specificity of 72.5%, and an accuracy of 92.2%. Positive and negative predictive were calculated at 41.7% and 100%, respectively.

Conclusions: The US finding of a close relationship with the glandular capsule is a highly sensitive diagnostic indicator for MM. Following this finding, US-guided needle biopsy should be recommended to further confirm the diagnosis.

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与腺体囊关系密切:超声诊断主要涎腺转移性恶性肿瘤的高灵敏度指标。
研究目的研究主要唾液腺转移性恶性肿瘤(MM)的超声(US)特征,并评估与腺体囊关系密切对识别MM的诊断价值:从2016年1月至2022年4月,122名主要唾液腺恶性肿瘤患者被纳入本研究,其中包括20名MM患者和102名经组织病理学检查证实的原发性恶性肿瘤(PM)患者。研究人员记录并分析了这些患者的临床病理和 US 数据。结果显示,MM的平均年龄大于原发性恶性肿瘤(PM)的平均年龄:MM的平均年龄比PM大(59.50 ± 14.57 vs. 49.96 ± 15.73,P = 0.013)。与 PM 患者相比,MM 患者的局部疼痛症状(P = 0.007)和面神经功能异常(P = 0.003)发生率更高:US 发现与腺囊关系密切是 MM 的一个高度敏感的诊断指标。根据这一发现,应建议在 US 引导下进行针刺活检以进一步确诊。
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来源期刊
CiteScore
5.60
自引率
9.10%
发文量
65
审稿时长
4-8 weeks
期刊介绍: Dentomaxillofacial Radiology (DMFR) is the journal of the International Association of Dentomaxillofacial Radiology (IADMFR) and covers the closely related fields of oral radiology and head and neck imaging. Established in 1972, DMFR is a key resource keeping dentists, radiologists and clinicians and scientists with an interest in Head and Neck imaging abreast of important research and developments in oral and maxillofacial radiology. The DMFR editorial board features a panel of international experts including Editor-in-Chief Professor Ralf Schulze. Our editorial board provide their expertise and guidance in shaping the content and direction of the journal. Quick Facts: - 2015 Impact Factor - 1.919 - Receipt to first decision - average of 3 weeks - Acceptance to online publication - average of 3 weeks - Open access option - ISSN: 0250-832X - eISSN: 1476-542X
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