Beatriz Santana Mendonça, Laura Maria Morales Nascimento, Jamylle Nunes de Souza Ferro, Maria Danielma Dos Santos Reis
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引用次数: 0
Abstract
Objective: Polyphenols are organic compounds with diverse biological activities such as anti-inflammatory and antioxidant effects, making them important candidates for the development of anti-aging drugs. In this systematic review, we aimed to answer the question: can plant-derived polyphenols have an immunomodulatory effect in experimental models of aging?
Methods: We systematically searched Web of Science, MEDLINE/Pubmed, and Embase to select articles using the following combinations of terms and synonyms: polyphenols, phenols, senescence, aging, and immune. The selected articles were evaluated for reporting quality and risk-of-bias according to standard guidelines.
Results: The most used polyphenol was resveratrol, followed by curcumin, salidroside, and gallic acid. These molecules demonstrated an ability to restore immune function both in vitro and in vivo. The mechanism of action was not completely elucidated in these studies, but inhibition of NF-kB signaling, and antioxidant properties seemed to account for the anti-aging effects. All articles included in the review had good quality of reporting but failed to describe an adequate sample size, criteria for inclusion/exclusion, randomization, and blinding.
Conclusion: We conclude that polyphenols are promising immunomodulatory substances for use in anti-aging therapies. However, more research with standardized analysis is needed to understand the role of these molecules in the prevention or reduction of damage associated with the aging process, as well as to determine the safety profile and consequences of systemic action.
目的：多酚是一种有机化合物，具有抗炎和抗氧化等多种生物活性，是开发抗衰老药物的重要候选物质。在这篇系统综述中，我们旨在回答这样一个问题：植物多酚能否在衰老实验模型中起到免疫调节作用？我们系统地检索了 Web of Science、MEDLINE/Pubmed 和 Embase，使用以下术语和同义词组合筛选文章：多酚、酚类、衰老、老化和免疫。根据标准指南对所选文章的报告质量和偏倚风险进行了评估：结果：使用最多的多酚是白藜芦醇，其次是姜黄素、水杨甙和没食子酸。这些分子在体外和体内都显示出恢复免疫功能的能力。这些研究没有完全阐明其作用机制，但抑制 NF-kB 信号传导和抗氧化特性似乎是抗衰老作用的原因。综述中收录的所有文章都具有良好的报告质量，但未能描述足够的样本量、纳入/排除标准、随机化和盲法：我们得出结论：多酚类物质是很有希望用于抗衰老疗法的免疫调节物质。然而，还需要进行更多的标准化分析研究，以了解这些分子在预防或减少与衰老过程相关的损伤方面的作用，并确定其安全性和全身作用的后果。
期刊介绍：
The journal Immunopharmacology and Immunotoxicology is devoted to pre-clinical and clinical drug discovery and development targeting the immune system. Research related to the immunoregulatory effects of various compounds, including small-molecule drugs and biologics, on immunocompetent cells and immune responses, as well as the immunotoxicity exerted by xenobiotics and drugs. Only research that describe the mechanisms of specific compounds (not extracts) is of interest to the journal.
The journal will prioritise preclinical and clinical studies on immunotherapy of disorders such as chronic inflammation, allergy, autoimmunity, cancer etc. The effects of small-drugs, vaccines and biologics against central immunological targets as well as cell-based therapy, including dendritic cell therapy, T cell adoptive transfer and stem cell therapy, are topics of particular interest. Publications pointing towards potential new drug targets within the immune system or novel technology for immunopharmacological drug development are also welcome.
With an immunoscience focus on drug development, immunotherapy and toxicology, the journal will cover areas such as infection, allergy, inflammation, tumor immunology, degenerative disorders, immunodeficiencies, neurology, atherosclerosis and more.
Immunopharmacology and Immunotoxicology will accept original manuscripts, brief communications, commentaries, mini-reviews, reviews, clinical trials and clinical cases, on the condition that the results reported are based on original, clinical, or basic research that has not been published elsewhere in any journal in any language (except in abstract form relating to paper communicated to scientific meetings and symposiums).
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