Pseudo-Orthostatic Tremor in Graves' Disease: A Possible Early Sign of Parkinsonism?

IF 2.5 Q2 CLINICAL NEUROLOGY Tremor and Other Hyperkinetic Movements Pub Date : 2024-07-24 eCollection Date: 2024-01-01 DOI:10.5334/tohm.924

Davide Comolli, Simone Regalbuto, Sebastiano Arceri, Giuseppe Trifirò, Alessandra Calculli, Carlo Fazio, Piergiorgio Grillo, Massimiliano Todisco, Antonio Pisani

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Abstract

Background: Pseudo-orthostatic tremor is a hyperkinetic movement disorder usually associated with other neurological comorbidities, mainly Parkinson's disease.

Case report: A 65-year-old male presented with unsteadiness and leg tremor while standing. Electrophysiological evaluation confirmed the presence of pseudo-orthostatic tremor. Blood test showed an undiagnosed Graves' disease. A complete remission of tremor was achieved with methimazole. Dopamine transporter scintigraphy showed a mild reduction of the striatal binding, bilaterally.

Discussion: Graves' disease can be associated with pseudo-orthostatic tremor. Thyroid function should be assessed in patients complaining of unsteadiness. The causative role of hyperthyroidism in determining dopaminergic degeneration and uncovering subclinical parkinsonism warrants further investigations.

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巴塞杜氏病的假性静止性震颤：帕金森病的可能早期征兆？

背景：假性直立性震颤是一种过度运动障碍，通常伴有其他神经系统合并症，主要是帕金森病：病例报告：一名 65 岁的男性在站立时出现站立不稳和腿部震颤。电生理评估证实其患有假性直立性震颤。血液检查显示他患有未确诊的巴塞杜氏病。使用甲巯咪唑后，震颤完全缓解。多巴胺转运体闪烁成像显示，双侧纹状体结合力轻度下降：讨论：巴塞杜氏病可伴有假性强直性震颤。主诉不稳的患者应评估甲状腺功能。甲状腺功能亢进症在决定多巴胺能变性和发现亚临床帕金森病方面的致病作用值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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