Left ventricular subclinical systolic myocardial dysfunction assessed by speckle-tracking in patients with Cushing's syndrome.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2024-11-01 Epub Date: 2024-07-29 DOI:10.1007/s12020-024-03980-4

Jiewen Jin, Wei He, Rong Huang, Pengyuan Zhang, Xiaoying He, Yang Peng, Zhihong Liao, Haipeng Xiao, Yanbing Li, Hai Li

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Abstract

Purpose: Two-dimensional speckle tracking echocardiography is a novel ultrasound technique, which can detect early subclinical myocardial dysfunction with high sensitivity. The purpose of this study was to explore the value of speckle tracking echocardiography in the evaluation of subclinical myocardial injury in patients with Cushing's syndrome.

Methods: 35 patients with Cushing's syndrome and 29 healthy controls matched for age, sex, BMI, and systolic blood pressure were included in the study. All subjects were assessed using both conventional Doppler echocardiography and speckle tracking echocardiography. Among patients, they were further divided into inactive group (n = 7) and active group (n = 28) based on cortisol levels. Trend analysis was used among patients in different disease activity. Correlation analysis and linear regression analysis were used to explore influence factors related to subclinical myocardial dysfunction.

Results: Left ventricular ejection fraction value showed no statistical difference between patients Cushing's syndrome and control group. However, GLS and LVSD, show significant differences in Cushing's syndrome group. Also, among active Cushing's syndrome group, inactive Cushing's syndrome group and control group, GLS (-15.4 ± 3.0 vs -18.1 ± 3.1 vs-19.4 ± 2.4, P < 0001) and LVSD (48.9 ± 21.5 vs 43.5 ± 17.9 vs 28.5 ± 8.3, P < 0001) changed significantly with the disease activity status. In addition, GLS and LVSD were both linearly corrected with 24-hour urinary cortisol level.

Conclusion: GLS and LVSD are sensitive parameters in detecting and monitoring subclinical myocardial systolic dysfunction in patients with Cushing's syndrome. Myocardial injury is linearly correlated with cortisol level, which can be partially reversed after the biochemical control of cortisol.

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通过斑点追踪技术评估库欣综合征患者的左心室亚临床收缩性心肌功能障碍。

目的：二维斑点追踪超声心动图是一种新型超声技术，可高灵敏度地检测早期亚临床心肌功能障碍。本研究旨在探讨斑点追踪超声心动图在评估库欣综合征患者亚临床心肌损伤中的价值。所有受试者均使用传统多普勒超声心动图和斑点追踪超声心动图进行评估。根据皮质醇水平将患者分为非活动组（7 人）和活动组（28 人）。对不同疾病活动度的患者进行趋势分析。采用相关分析和线性回归分析来探讨与亚临床心肌功能障碍相关的影响因素：结果：库欣综合征患者的左心室射血分数与对照组无统计学差异。但是，库欣综合征组的 GLS 和 LVSD 有显著差异。此外，在活动性库欣综合征组、非活动性库欣综合征组和对照组中，GLS（-15.4 ± 3.0 vs -18.1 ± 3.1 vs-19.4 ± 2.4，P 结论：GLS 和 LVSD 是库欣综合征患者的敏感指标：GLS和LVSD是检测和监测库欣综合征患者亚临床心肌收缩功能障碍的敏感参数。心肌损伤与皮质醇水平呈线性相关，在对皮质醇进行生化控制后可部分逆转。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.