Difference between subjective and objective cognitive decline confirmed by power spectral density.

IF 1.5 4区医学 Q3 PSYCHIATRY Cognitive Neuropsychiatry Pub Date : 2024-05-01 Epub Date: 2024-07-28 DOI:10.1080/13546805.2024.2364960

Ho Tae Jeong, Young Chul Youn, Kwang-Yeol Park, Byung-Sun Choi, Taek-Kyun Nam, Hyun Ho Sung

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Abstract

Introduction: The study aims to use power spectrum changes in subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI), preclinical stages of Alzheimer's disease (AD), for future biomarker studies in early AD diagnosis.

Methods: We recruited 23 SCD and 32 aMCI subjects and conducted comparative analysis using relative power spectral density (PSD). Automated preprocessing and statistical analysis were performed using iSync Brain® (iMediSync Inc., Republic of Korea) (https://isyncbrain.com/).

Results: Theta band power in the temporal region was 14.826 ± 7.2394 for the SCD group and 20.003 ± 10.1768 for the aMCI group. In the parietal region, theta band power was 13.614 ± 7.5689 for SCD and 19.894 ± 11.1387 for aMCI. Beta1 band power in the frontal region was 6.639 ± 2.2904 for SCD and 5.465 ± 1.8907 for aMCI, and in the temporal region it was 7.359 ± 2.5619 for SCD and 5.921 ± 2.1605 for aMCI.

Conclusion: PSD analysis of resting-state EEG predicted SCD, a preclinical stage of AD. This cross-sectional study observed electrical-physiological characteristics of preclinical AD; however, follow-up studies are needed to evaluate predictive value for future cognitive decline.

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功率谱密度证实了主观和客观认知能力下降之间的差异。

研究简介本研究旨在利用阿尔茨海默病（AD）临床前阶段--主观认知能力下降（SCD）和失忆性轻度认知障碍（aMCI）的功率谱变化，为未来早期诊断AD的生物标记物研究提供依据：我们招募了 23 名 SCD 和 32 名 aMCI 受试者，并使用相对功率谱密度 (PSD) 进行了比较分析。使用 iSync Brain® (iMediSync Inc., Republic of Korea)（https://isyncbrain.com/）进行自动预处理和统计分析：结果：SCD 组颞区的 Theta 波段功率为 14.826 ± 7.2394，aMCI 组为 20.003 ± 10.1768。在顶叶区，SCD 组的 Theta 波段功率为 13.614 ± 7.5689，aMCI 组为 19.894 ± 11.1387。在额叶区，SCD 的 Beta1 波段功率为 6.639 ± 2.2904，aMCI 为 5.465 ± 1.8907；在颞叶区，SCD 的 Beta1 波段功率为 7.359 ± 2.5619，aMCI 为 5.921 ± 2.1605：结论：静息态脑电图的 PSD 分析可预测 SCD，SCD 是 AD 的临床前阶段。这项横断面研究观察到了临床前注意力缺失症的电生理特征；然而，还需要进行后续研究，以评估其对未来认知能力下降的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cognitive Neuropsychiatry PSYCHIATRY-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

>12 weeks

期刊介绍： Cognitive Neuropsychiatry (CNP) publishes high quality empirical and theoretical papers in the multi-disciplinary field of cognitive neuropsychiatry. Specifically the journal promotes the study of cognitive processes underlying psychological and behavioural abnormalities, including psychotic symptoms, with and without organic brain disease. Since 1996, CNP has published original papers, short reports, case studies and theoretical and empirical reviews in fields of clinical and cognitive neuropsychiatry, which have a bearing on the understanding of normal cognitive processes. Relevant research from cognitive neuroscience, cognitive neuropsychology and clinical populations will also be considered. There are no page charges and we are able to offer free color printing where color is necessary.

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