Angio-microRNAs in diabetic foot ulcer-: Mechanistic insights and clinical perspectives

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Progress in Biophysics & Molecular Biology Pub Date : 2024-07-27 DOI:10.1016/j.pbiomolbio.2024.07.006

Mohammad Hasan Soheilifar , Nastaran Masoudi-Khoram , Mahmoud Hassani , Amirhossein Hajialiasgary Najafabadi , Mahdieh Khojasteh , Hoda Keshmiri Neghab , Zahra Jalili

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Abstract

Diabetic foot ulcers, as one of the chronic wounds, are a serious challenge in the global healthcare system which have shown notable growth in recent years. DFU is associated with impairment in various stages of wound healing, including angiogenesis. Aberrant expression of microRNAs (miRNAs) involved in the disruption of the balance between angiogenic and anti-angiogenic factors, plays a crucial role in angiogenesis dysfunction. Alteration in the expression of angiomiRNAs (angiomiRs) have the potential to function as biomarkers in chronic wounds. Additionally, considering the rising importance of therapeutic RNAs, there is potential for utilizing angiomiRs in wound healing to induce angiogenesis. This review aims to explore angiogenesis in chronic wounds and investigate the mechanisms mediated by pro- and anti-angiomiRs in the context of diabetic foot ulcers.

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糖尿病足溃疡中的血管微核糖核酸：机理认识与临床展望。

糖尿病足溃疡是慢性伤口之一，是全球医疗保健系统面临的严峻挑战，近年来呈显著增长趋势。糖尿病足溃疡与伤口愈合的各个阶段（包括血管生成）受损有关。微小核糖核酸（miRNA）的表达异常参与了血管生成因子和抗血管生成因子之间平衡的破坏，在血管生成功能障碍中起着至关重要的作用。angiomiRNAs （angiomiRs）表达的变化有可能成为慢性伤口的生物标志物。此外，考虑到治疗用 RNAs 的重要性不断上升，在伤口愈合中利用血管噬菌体 RNAs 诱导血管生成的可能性也很大。本综述旨在探讨慢性伤口中的血管生成，并研究糖尿病足溃疡中促血管生成RNA和抗血管生成RNA介导的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Biophysics & Molecular Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

7.90%

发文量

审稿时长

85 days

期刊介绍： Progress in Biophysics & Molecular Biology is an international review journal and covers the ground between the physical and biological sciences since its launch in 1950. It indicates to the physicist the great variety of unsolved problems awaiting attention in biology and medicine. The biologist and biochemist will find that this journal presents new and stimulating ideas and novel approaches to studying and influencing structural and functional properties of the living organism. This journal will be of particular interest to biophysicists, biologists, biochemists, cell physiologists, systems biologists, and molecular biologists.