Association between triglyceride to HDL cholesterol ratio and a risk of diabetes mellitus: a systematic review and meta-analysis.

Laboratory medicine Pub Date : 2024-07-27 DOI:10.1093/labmed/lmae052

Hongjing Zhong, Laiming Luo, Xiaomei Wang, Yao Xiao

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Abstract

Objective: The aim of this study was to investigate the link between the triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) and the occurrence of type 2 diabetes mellitus (T2DM).

Methods: PubMed, Embase, and Scopus databases were searched for cohort and case-control studies that reported on the link between TG/HDL-C and a risk of T2DM, with no restrictions on criteria used for the definition and categorization of low and high TG/HDL-C ratios.

Results: A total of 20 studies were included. There was considerable variability in terms of categorization of low or normal and higher TG/HDL-C ratio among the studies. Patients with high TG/HDL-C ratio had markedly higher risk of developing T2DM compared with patients with low or normal TG/HDL-C. Each unit increase in the ratio correlated with the increased risk of diabetes. Subgroup analysis based on sex showed an increased risk of T2DM in males and females with a high ratio compared with the group with a low/normal ratio.

Conclusion: Higher TG/HDL-C ratio correlates with increased risk of T2DM. Despite limitations, the study demonstrates a possible value of using TG/HDL-C ratio as a biomarker for diabetes risk.

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甘油三酯与高密度脂蛋白胆固醇比率与糖尿病风险之间的关系：系统回顾和荟萃分析。

研究目的本研究旨在探讨甘油三酯与高密度脂蛋白胆固醇比率（TG/HDL-C）与 2 型糖尿病（T2DM）发生率之间的联系：方法：在 PubMed、Embase 和 Scopus 数据库中检索了报道 TG/HDL-C 与 T2DM 风险之间关系的队列研究和病例对照研究，对 TG/HDL-C 低比率和高比率的定义和分类标准没有限制：结果：共纳入 20 项研究。结果：共纳入 20 项研究，这些研究在 TG/HDL-C 比率低或正常和高的分类方面存在很大差异。与 TG/HDL-C 比率低或正常的患者相比，TG/HDL-C 比率高的患者患 T2DM 的风险明显更高。该比率每增加一个单位，患糖尿病的风险就增加一个单位。基于性别的分组分析显示，与低/正常比值组相比，高比值的男性和女性患 T2DM 的风险更高：结论：TG/HDL-C 比率越高，T2DM 风险越高。结论：TG/HDL-C 比率越高，患 T2DM 的风险越高。尽管存在局限性，但该研究证明了使用 TG/HDL-C 比率作为糖尿病风险生物标志物的可能价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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