ANZTCT practice statement: sinusoidal obstruction syndrome/veno-occlusive disease diagnosis and management

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Internal Medicine Journal Pub Date : 2024-07-30 DOI:10.1111/imj.16453

Shaun Fleming, Ashleigh P. Scott, John Coutsouvelis, Chris Fraser, Ashish Bajel, Adam Nelson, Rachel Conyers, Ashley McEwan, David Yeung, Victoria Campion, Lochie Teague, Matthew McGuire, Edward Morris, Melissa Gabriel, Rebecca Wayte, Genevieve Douglas, Nicole Chien, Nada Hamad

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Abstract

Sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication which can develop after haemopoietic stem cell transplantation (HSCT) and some antibody–drug conjugates. Several SOS/VOD diagnostic and management guidelines exist, with the most recent and refined being the European Society for Blood and Marrow Transplantation adult and paediatric guidelines. Timely diagnosis and effective management (including the availability of therapeutic options) significantly contribute to improved patient outcomes. In Australia and New Zealand, there is variability in clinical practice and access to SOS/VOD therapies. This review aims to summarise the current evidence for SOS/VOD diagnosis, prevention and treatment and to provide recommendations for SOS/VOD in the context of contemporary Australasian HSCT clinical practice.

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ANZTCT 实践声明：窦性阻塞综合征/静脉闭塞症的诊断和管理。

窦性阻塞综合征/静脉闭塞性疾病（SOS/VOD）是造血干细胞移植（HSCT）和某些抗体药物共轭物治疗后可能出现的一种危及生命的并发症。目前已有多份 SOS/VOD 诊断和管理指南，其中最新和最完善的是欧洲血液与骨髓移植学会成人和儿科指南。及时诊断和有效管理（包括提供治疗方案）大大有助于改善患者的预后。在澳大利亚和新西兰，SOS/VOD疗法的临床实践和使用情况存在差异。本综述旨在总结有关 SOS/VOD 诊断、预防和治疗的现有证据，并结合当代澳大利亚造血干细胞移植临床实践为 SOS/VOD 提供建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine Journal 医学-医学：内科

CiteScore

3.50

自引率

4.80%

发文量

600

审稿时长

3-6 weeks

期刊介绍： The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.

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