Role of uric acid in neurodegenerative diseases, focusing on Alzheimer and Parkinson disease: A new perspective.

IF 2 Q3 NEUROSCIENCES Neuropsychopharmacology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-29 DOI:10.1002/npr2.12445

Mohammed Alrouji, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Mohammed S Alshammari, Athanasios Alexiou, Marios Papadakis, Mostafa M Bahaa, Gaber El-Saber Batiha

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Abstract

Neurodegenerative diseases (NDs) such as Alzheimer disease (AD) and Parkinson disease (PD) are group of diseases affecting the central nervous system (CNS) characterized by progressive neurodegenerations and cognitive impairment. Findings from different studies highlighted the beneficial and detrimental effects of serum uric acid on the development and progression of NDs. Therefore, this mini-review aims to discuss the beneficial and detrimental effects of uric on NDs. The neuroprotective effect of uric acid is mainly related to the antioxidant effect of uric acid which alleviates oxidative stress-induced neurodegeneration in AD and PD. However, long-term effect of hyperuricemia prompts for the development and progression of cognitive impairment. Hyperuricemia is associated with cognitive impairment and dementia, and gout increases dementia risk. In addition, hyperuricemia can cause cerebral vascular injury which is a risk factor for vascular dementia and cognitive impairment. Taken together, the relationship between uric acid and NDs risk remains conflicting. Hence, preclinical and clinical studies are indicated in this regard.

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尿酸在神经退行性疾病（重点是阿尔茨海默病和帕金森病）中的作用：新视角。

神经退行性疾病（NDs），如阿尔茨海默病（AD）和帕金森病（PD），是一组影响中枢神经系统（CNS）的疾病，其特征是进行性神经退行性变和认知功能障碍。不同研究的结果表明，血清尿酸对 NDs 的发生和发展有利有弊。因此，本微型综述旨在讨论尿酸对 NDs 的有利和不利影响。尿酸的神经保护作用主要与尿酸的抗氧化作用有关，尿酸的抗氧化作用可减轻氧化应激诱导的 AD 和 PD 神经变性。然而，高尿酸血症的长期效应会促使认知障碍的发生和发展。高尿酸血症与认知障碍和痴呆症有关，痛风会增加痴呆症风险。此外，高尿酸血症可导致脑血管损伤，而脑血管损伤是血管性痴呆和认知障碍的风险因素。综上所述，尿酸与 NDs 风险之间的关系仍然相互矛盾。因此，在这方面需要进行临床前和临床研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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