Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-30 DOI:10.1097/MPA.0000000000002393

Ivana Acimovic, Viktorie Gabrielová, Stanislava Martínková, Michal Eid, Jakub Vlažný, Petr Moravčík, Jan Hlavsa, Lukáš Moráň, Riza Can Cakmakci, Peter Staňo, Vladimír Procházka, Zdeněk Kala, Jan Trnka, Petr Vaňhara

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Abstract

Abstract: Pancreas is a vital gland of gastro-intestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a five-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, the identification of novel molecular targets, and the development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing three-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.

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胰腺导管腺癌的体外三维细胞模型：从胚胎发育到精准肿瘤学。

摘要：胰腺是胃肠系统的重要腺体，具有外分泌和内分泌功能，与人体重要的新陈代谢回路交织在一起。胰腺导管腺癌（PDAC）是最致命的恶性肿瘤之一，五年生存率仅为 11%。预后不良的主要原因是没有早期症状、转移扩散快以及目前的治疗干预措施疗效有限。尽管最近在了解 PDAC 的发病机制和治疗方面取得了进展，但仍迫切需要改进个体化模型、确定新的分子靶点以及开发无偏见的疾病进展预测指标。在此，我们旨在利用胰腺肿瘤的三维患者特异性细胞模型探索精准医疗的概念，并讨论它们在发现新的药物分子靶点和预测个体患者临床参数方面的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.