Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma: From Embryonic Development to Precision Oncology.

IF 1.7 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pancreas Pub Date : 2025-01-01 Epub Date: 2024-07-30 DOI:10.1097/MPA.0000000000002393

Ivana Acimovic, Viktorie Gabrielová, Stanislava Martínková, Michal Eid, Jakub Vlažný, Petr Moravčík, Jan Hlavsa, Lukáš Moráň, Riza Can Cakmakci, Peter Staňo, Vladimír Procházka, Zdeněk Kala, Jan Trnka, Petr Vaňhara

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Abstract

Abstract: Pancreas is a vital gland of gastrointestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a 5-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, identification of novel molecular targets, and development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing 3-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.

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胰腺导管腺癌的体外三维细胞模型：从胚胎发育到精准肿瘤学。

摘要：胰腺是胃肠系统的重要腺体，具有外分泌和内分泌功能，与人体重要的新陈代谢回路交织在一起。胰腺导管腺癌（PDAC）是最致命的恶性肿瘤之一，五年生存率仅为 11%。预后不良的主要原因是没有早期症状、转移扩散快以及目前的治疗干预措施疗效有限。尽管最近在了解 PDAC 的发病机制和治疗方面取得了进展，但仍迫切需要改进个体化模型、确定新的分子靶点以及开发无偏见的疾病进展预测指标。在此，我们旨在利用胰腺肿瘤的三维患者特异性细胞模型探索精准医疗的概念，并讨论它们在发现新的药物分子靶点和预测个体患者临床参数方面的潜在应用。

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来源期刊

Pancreas 医学-胃肠肝病学

CiteScore

4.70

自引率

3.40%

发文量

289

审稿时长

1 months

期刊介绍： Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.