Characterization of clinical trials in Ecuador and their association with disease burden: Are there research gaps?

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-26 DOI:10.4103/jfmpc.jfmpc_1181_23
Carla Salgado, Josue Rivadeneira, Nayely García Méndez, Carlos Manterola
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Abstract

ABSTRACT This study offers a detailed analysis of clinical trials conducted in Ecuador from 2010 to 2022 to assess alignment with the country’s disease burden as indicated by the Global Burden of Disease study. Utilizing data from five registries, including ARCSA and Clinicaltrials.gov, we analyzed characteristics and coverage of 75 CTs after removing duplicates and ineligible studies. Findings reveal a 50% research gap across disease groups, with neoplasms being the only category matching disease burden. The scarcity of clinical research highlights the disparity between CTs and prevalent diseases such as cardiovascular and kidney diseases, diabetes, and other non-communicable conditions. Our results underscore the urgent need for increased clinical research investment addressing these critical health challenges in Ecuador.
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厄瓜多尔临床试验的特点及其与疾病负担的关系:是否存在研究空白?
摘要 本研究详细分析了 2010 年至 2022 年在厄瓜多尔开展的临床试验,以评估与全球疾病负担研究(Global Burden of Disease)显示的该国疾病负担的一致性。利用来自五个登记处(包括 ARCSA 和 Clinicaltrials.gov)的数据,我们分析了 75 项临床试验的特征和覆盖范围,并剔除了重复和不合格的研究。研究结果显示,各疾病组的研究缺口达 50%,而肿瘤是唯一与疾病负担相匹配的类别。临床研究的匮乏凸显了 CT 与心血管疾病、肾脏疾病、糖尿病和其他非传染性疾病等流行疾病之间的差距。我们的研究结果突出表明,厄瓜多尔迫切需要增加临床研究投资,以应对这些严峻的健康挑战。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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