APOE4, activation of latent form HSV-1, A beta accumulation and AD progression

Abstract

The role of APOE4 in Alzheimers disease progression is an area of ongoing research. The core objective of this paper is to investigate the intricate interplay between APOE4, HSV-1, A, and AD progression. Methodology involves assessing A Levels, Spatial Recognition Memory, and Exploratory Behavior in HSV-1-infected Fx5AD Mice with APOE4, alongside monitoring specific biomarkers to confirm HSV-1 activation status. Our expected experimental outcomes suggest that APOE4 accelerates latent HSV-1 activation, leading to heightened A aggregation. Thus, we hypothesize that APOE4 may expedite latent HSV-1 activation, thereby facilitating A accumulation and AD advancement. The investigation of relationship between APOE4, HSV-1, A, and AD progression could give valuable insights into further experiments and treatments of AD.