Interdisciplinary strategies for diagnosis and treatment of trigeminal neuralgia

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-07-24 DOI:10.57187/s.3460
Lukasz Kolakowski, Heiko Pohl, Lennart Stieglitz, Anthony De Vere-Tyndall, Michael B. Soyka, Patrizia Räber-Jäggy, Julia Wagner, Constantina V. Marinescu, Michelle L. Brown, Michael Blumer, Günter T. Müller, Susanne Wegener
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Abstract

Temporary, sudden, shooting and recurrent unilateral facial pain in the supply area of one or more trigeminal nerve branches characterises trigeminal neuralgia. Innocuous stimuli trigger the pain, e.g. chewing, speaking or brushing teeth. In some patients, paroxysms superimpose on continuous pain. In aetiological terms, idiopathic, classic (due to neurovascular compression) and secondary trigeminal neuralgia (e.g. due to multiple sclerosis, brainstem ischaemia and space-occupying lesions) are defined. Many drugs may be efficacious, with carbamazepine being first-choice therapy. However, non-pharmacological and invasive procedures may also help. To reach the correct diagnosis and determine the best therapeutic measures, adequate pain characterisation and interdisciplinary collaboration are essential. We hereby present our experience of an interdisciplinary approach for the diagnosis and treatment of trigeminal neuralgia.
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诊断和治疗三叉神经痛的跨学科策略
三叉神经痛的特征是在一个或多个三叉神经分支的供血区出现暂时性、突发性、射击样和反复发作的单侧面部疼痛。咀嚼、说话或刷牙等无害刺激会引发疼痛。有些患者会在持续疼痛的基础上叠加阵发性疼痛。在病因学方面,三叉神经痛可分为特发性、典型性(神经血管受压所致)和继发性(如多发性硬化、脑干缺血和空间占位性病变所致)。许多药物都有疗效,卡马西平是首选疗法。不过,非药物治疗和侵入性治疗也可能有帮助。要得出正确的诊断并确定最佳治疗措施,充分的疼痛特征描述和跨学科合作至关重要。我们在此介绍跨学科方法诊断和治疗三叉神经痛的经验。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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