Rare occurrence of sagittal sinus thrombosis and haemorrhagic infarction with dengue fever; jumping from traditional symptoms to lethal neurological consequences

Khabab Abbasher Hussien Mohamed Ahmed, AlHussein Abbasher, A. Siddig, Mohammed Abbasher, Abubaker Alsedig Abbasher, Ali Abdelhaleem Omar Ahmed, Zinab Shihab Hamednalla Abdelgader, Esraa Hassan Salih Elhaj, Areeba Ahsan, Ghassan E. Mustafa Ahmed, A. Hussien
{"title":"Rare occurrence of sagittal sinus thrombosis and haemorrhagic infarction with dengue fever; jumping from traditional symptoms to lethal neurological consequences","authors":"Khabab Abbasher Hussien Mohamed Ahmed, AlHussein Abbasher, A. Siddig, Mohammed Abbasher, Abubaker Alsedig Abbasher, Ali Abdelhaleem Omar Ahmed, Zinab Shihab Hamednalla Abdelgader, Esraa Hassan Salih Elhaj, Areeba Ahsan, Ghassan E. Mustafa Ahmed, A. Hussien","doi":"10.1097/ms9.0000000000002406","DOIUrl":null,"url":null,"abstract":"\n \n Dengue virus (DENV) is an RNA virus transmitted by Aides mosquito causing Dengue fever. There is growing recognition of neurological symptoms associated with DENV infection, some of which might be lethal if left untreated. Case reports describing sagittal sinus thrombosis, as a serious neurologic consequence of dengue infection, are rare. It is still unknown how often sagittal sinus thrombosis occurs and what variables increase the risk in dengue patients.\n \n \n \n Herein we presented an elderly Sudanese patient diagnosed with Dengue fever. He was admitted, then two days after admission the condition was complicated by atrial fibrillation, sagittal sinus thrombosis complicated by massive left temporal lobe infarction with haemorrhagic transformation and recurrent episodes of status epilepticus. After receiving the necessary care, his condition remained the same and no progress or deterioration was seen.\n \n \n \n Sagittal sinus thrombosis can happen due to several underlying causes. DENV can very rarely lead to such condition. Our patient developed this condition which was later complicated by ischemic stroke with haemorrhagic transformation and status epilepticus. In addition to a familial history of DVT and a history of myocardial infarction, our patient also acquired cardiac mural thrombus and DVT throughout his illness, which increased the suspicion of a protein C, protein S, or antithrombin 3 deficiency.\n \n \n \n Sagittal sinus thrombosis with haemorrhagic infarction associated with thrombocytopenia is a very rare kind of stroke that occurs in dengue. Dengue as a pathogenic mechanism of ischemic stroke requires validation with further data.\n","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"72 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Medicine & Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/ms9.0000000000002406","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Dengue virus (DENV) is an RNA virus transmitted by Aides mosquito causing Dengue fever. There is growing recognition of neurological symptoms associated with DENV infection, some of which might be lethal if left untreated. Case reports describing sagittal sinus thrombosis, as a serious neurologic consequence of dengue infection, are rare. It is still unknown how often sagittal sinus thrombosis occurs and what variables increase the risk in dengue patients. Herein we presented an elderly Sudanese patient diagnosed with Dengue fever. He was admitted, then two days after admission the condition was complicated by atrial fibrillation, sagittal sinus thrombosis complicated by massive left temporal lobe infarction with haemorrhagic transformation and recurrent episodes of status epilepticus. After receiving the necessary care, his condition remained the same and no progress or deterioration was seen. Sagittal sinus thrombosis can happen due to several underlying causes. DENV can very rarely lead to such condition. Our patient developed this condition which was later complicated by ischemic stroke with haemorrhagic transformation and status epilepticus. In addition to a familial history of DVT and a history of myocardial infarction, our patient also acquired cardiac mural thrombus and DVT throughout his illness, which increased the suspicion of a protein C, protein S, or antithrombin 3 deficiency. Sagittal sinus thrombosis with haemorrhagic infarction associated with thrombocytopenia is a very rare kind of stroke that occurs in dengue. Dengue as a pathogenic mechanism of ischemic stroke requires validation with further data.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
登革热并发矢状窦血栓和出血性脑梗塞的罕见病例;从传统症状到致命性神经系统后果的转变
登革热病毒(DENV)是一种由艾氏蚊子传播的 RNA 病毒,可引起登革热。越来越多的人认识到与登革热病毒感染相关的神经系统症状,其中一些症状如不及时治疗可能会致命。描述矢状窦血栓形成是登革热感染导致的严重神经系统后果的病例报告并不多见。矢状窦血栓形成的发生率有多高,登革热病人发生矢状窦血栓形成的风险因哪些变量而增加,目前仍是未知数。 在此,我们介绍了一名被诊断为登革热的苏丹老年患者。入院两天后,他的病情因心房颤动、矢状窦血栓形成并发大面积左颞叶梗死伴出血性转变和反复发作的癫痫状态而变得复杂。在接受了必要的治疗后,他的病情保持不变,没有任何进展或恶化。 矢状窦血栓可由多种潜在原因引起。DENV 很少会导致这种情况。我们的患者就是这种情况,后来并发了缺血性中风伴出血性转变和癫痫状态。除了有深静脉血栓形成的家族史和心肌梗死史外,我们的患者在整个病程中还出现了心脏壁血栓和深静脉血栓形成,这增加了对蛋白 C、蛋白 S 或抗凝血酶 3 缺乏症的怀疑。 矢状窦血栓形成伴出血性脑梗死与血小板减少症是登革热患者中非常罕见的一种中风。登革热作为缺血性中风的致病机制需要进一步的数据验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Biliary atresia with rare associations: a case report and literature review Unveiling the uncommon: A case report of avascular necrosis in the triquetrum bone without trauma A pocket practical guide on bibliometric analysis: bridging informatics with science in a rapid manner Anomalous left coronary artery from the pulmonary artery in a symptomatic adult, a case report Challenges in diagnosing and managing hyper-IgE syndrome in a resource-limited setting: a case report
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1