Reverse thinking: Tumor nutritional therapy

BMEMat Pub Date : 2024-07-20 DOI:10.1002/bmm2.12114
Binbin Ding, Ping'an Ma, Abdulaziz A. Al Kheraif, Jun Lin
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Abstract

Tumor cells often exhibit metabolic abnormalities to meet the needs of rapid proliferation, and targeting tumor metabolism has become one of the effective strategies for cancer treatment. However, most of the current methods targeting metabolism focus on inhibiting hyperactivated metabolic pathways, hindering their further application. A recent innovative work, proposed a nutrient-based strategy to reactivate metabolism for tumor therapy by targeting suppressed metabolic pathways. This approach through delivering nutrients to tumor cells directly using nanotechnology indicates that specific nutrients can serve as potent activators of metabolic pathways. As a new direction along the reverse thinking, this study suggests that this nutrient-based metabolism reactivation strategy will inspire broad applications in the treatment of other diseases associated with metabolic disorders, besides tumor.

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逆向思维肿瘤营养疗法
肿瘤细胞为了满足快速增殖的需要,往往会出现新陈代谢异常,因此靶向肿瘤新陈代谢已成为治疗癌症的有效策略之一。然而,目前大多数靶向代谢的方法都侧重于抑制过度激活的代谢途径,阻碍了它们的进一步应用。最近的一项创新工作提出了一种基于营养素的策略,通过靶向被抑制的代谢途径来重新激活代谢,从而治疗肿瘤。这种利用纳米技术直接向肿瘤细胞输送营养物质的方法表明,特定的营养物质可以作为代谢途径的有效激活剂。作为逆向思维的一个新方向,这项研究表明,这种基于营养素的新陈代谢再激活策略将被广泛应用于治疗除肿瘤以外的其他与代谢紊乱相关的疾病。
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