Two pemphigoid cases with mucous membrane involvement successfully treated with baricitinib

Tamás Malkovics, Orsolya N. Horváth, Miklós Sárdy
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Abstract

Both bullous pemphigoid and mucous membrane pemphigoid are autoimmune bullous diseases that can be challenging to treat in individual cases. Janus kinase inhibitors have shown efficacy in several autoimmune and inflammatory diseases, although these drugs are not yet widely used in autoimmune bullous diseases. We report two recalcitrant cases of pemphigoid with mucous membrane involvement which were successfully treated with the JAK 1/2 inhibitor baricitinib after all other feasible therapeutic options had been exhausted.
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巴利替尼成功治疗两例粘膜受累的丘疹性荨麻疹病例
大疱性类天疱疮和粘膜大疱性类天疱疮都是自身免疫性大疱性疾病,对个别病例的治疗具有挑战性。Janus 激酶抑制剂已在多种自身免疫性和炎症性疾病中显示出疗效,但这些药物尚未广泛用于自身免疫性大疱性皮肤病。我们报告了两例粘膜受累的顽固性丘疹性荨麻疹病例,在用尽了所有其他可行的治疗方案后,这两例患者成功地接受了JAK 1/2抑制剂巴利替尼的治疗。
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Issue Information Itch improvement has a major and comparable effect on the Dermatology Life Quality Index in psoriasis and atopic dermatitis patients Issue Information Sjögren syndrome from a dermatological perspective: A retrospective study of 185 SSA‐Ro positive patients Two pemphigoid cases with mucous membrane involvement successfully treated with baricitinib
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