A Review of the Histopathology of Nail Unit Tumors Including Selection of the Optimal Surgical Sampling

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-15 DOI:10.1159/000539383
Annie Jin, Dylan Haynes, Olaf Rodriguez, Ji Hye Park, Nathaniel Jellinek, A. Rubin
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Abstract

Background: A wide variety of tumors can affect the nail unit, with some commonly mistaken as inflammatory or infectious diseases. Obtaining an optimal sample for histopathologic evaluation requires understanding of nail unit anatomy as well as the histopathology of the suspected nail tumor. Summary: This review discusses clinical and histopathologic features of a subset of benign and malignant nail tumors, including subungual melanoma, nail unit squamous cell carcinoma in situ, nail unit squamous cell carcinoma, onychomatricoma, onychopapilloma, onychocytic matricoma, and onychocytic carcinoma. Optimal surgical sampling techniques for each lesion are presented. Key Messages: In summary, the clinical and histopathologic features of several common and rare nail unit tumors and the optimal sampling techniques for each lesion are presented in this manuscript. Knowledge of the clinical and histopathologic features of these tumors informs the surgical approach to them and will produce the best patient outcomes.
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甲单位肿瘤组织病理学综述,包括最佳手术取样的选择
背景:影响甲单位的肿瘤种类繁多,有些肿瘤通常被误认为是炎症或感染性疾病。要获得组织病理学评估的最佳样本,需要了解甲单位解剖以及疑似甲肿瘤的组织病理学。摘要:这篇综述讨论了一部分良性和恶性甲肿瘤的临床和组织病理学特征,包括甲下黑色素瘤、甲单位鳞状细胞原位癌、甲单位鳞状细胞癌、甲绒毛膜瘤、甲绒毛膜甲乳头状瘤、甲绒毛膜母细胞瘤和甲绒毛膜母细胞癌。介绍了针对每种病变的最佳手术取样技术。关键信息:综上所述,本手稿介绍了几种常见和罕见甲单位肿瘤的临床和组织病理学特征,以及每种病变的最佳取样技术。对这些肿瘤的临床和组织病理学特征的了解可为手术方法提供参考,并为患者带来最佳治疗效果。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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