Vanillin and 4-nitroanilline derived Schiff-base and its nickel(II) complex: spectral analysis and antibacterial investigation

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-12 DOI:10.4314/bcse.v38i5.7

Kasanesh Misganaw, Ponnusamy Thillairasu, Gemechu Shumi, Habtamu Debebe, Sintayehu Berhanu

{"title":"Vanillin and 4-nitroanilline derived Schiff-base and its nickel(II) complex: spectral analysis and antibacterial investigation","authors":"Kasanesh Misganaw, Ponnusamy Thillairasu, Gemechu Shumi, Habtamu Debebe, Sintayehu Berhanu","doi":"10.4314/bcse.v38i5.7","DOIUrl":null,"url":null,"abstract":"Ni(II) metal complex of Schiff base (SB) ligand 2-methoxy-4-[(4-nitrophenyl) iminomethyl]phenol (MNIMP); derived from vanillin and 4-nitroanilline was synthesized in 1:2 M:L by refluxing solution containing metal salt (NiCl2.6H2O, 97.0%) and SB in ethanol and characterized based on powder (XRD), NMR, FT-IR, UV-Vis spectrophotometer, and physicochemical measurements. The FT-IR spectra revealed that the complex is coordinated through azomethine nitrogen and phenolic oxygen of the bi-dentate ligands. The chemical shift δ = 9.8 ppm in 1H-NMR of SB; corresponds to the azomethine proton of the ligand suggesting the presence of -C=N- linkage and 13C-NMR confirms the presence of 14C in the ligand and the complex. The shift to a lower wavelength of UV-Vis spectra of the complex compared to the ligand signifying complex formation. The powder (XRD) pattern put forward the crystalline phase of the complex through nickel(II) occupying the center of octahedron geometry. The higher molar conductance value of the complex confirms its electrolytic nature. In-vitro antibacterial activities for synthesized compounds have been evaluated towards human pathogenic microbes Staphylococcus aureus and Escherichia coli and compared with standard, gentamicin. The result demonstrated that Ni(II) complex; [Ni (MNIMP)2(H2O)2]Cl2 has greater zone of inhibition against the tested organism than free MNIMP ligand as antibacterial agent. \nKEY WORDS: Derivatization, Schiff base ligand, Vanillin, Nickel (II) complex, Bi-dentate, Antibacterial activity \nBull. Chem. Soc. Ethiop. 2024, 38(5), 1275-1289. \nDOI: https://dx.doi.org/10.4314/bcse.v38i5.7 ","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.4314/bcse.v38i5.7","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Ni(II) metal complex of Schiff base (SB) ligand 2-methoxy-4-[(4-nitrophenyl) iminomethyl]phenol (MNIMP); derived from vanillin and 4-nitroanilline was synthesized in 1:2 M:L by refluxing solution containing metal salt (NiCl2.6H2O, 97.0%) and SB in ethanol and characterized based on powder (XRD), NMR, FT-IR, UV-Vis spectrophotometer, and physicochemical measurements. The FT-IR spectra revealed that the complex is coordinated through azomethine nitrogen and phenolic oxygen of the bi-dentate ligands. The chemical shift δ = 9.8 ppm in 1H-NMR of SB; corresponds to the azomethine proton of the ligand suggesting the presence of -C=N- linkage and 13C-NMR confirms the presence of 14C in the ligand and the complex. The shift to a lower wavelength of UV-Vis spectra of the complex compared to the ligand signifying complex formation. The powder (XRD) pattern put forward the crystalline phase of the complex through nickel(II) occupying the center of octahedron geometry. The higher molar conductance value of the complex confirms its electrolytic nature. In-vitro antibacterial activities for synthesized compounds have been evaluated towards human pathogenic microbes Staphylococcus aureus and Escherichia coli and compared with standard, gentamicin. The result demonstrated that Ni(II) complex; [Ni (MNIMP)2(H2O)2]Cl2 has greater zone of inhibition against the tested organism than free MNIMP ligand as antibacterial agent. KEY WORDS: Derivatization, Schiff base ligand, Vanillin, Nickel (II) complex, Bi-dentate, Antibacterial activity Bull. Chem. Soc. Ethiop. 2024, 38(5), 1275-1289. DOI: https://dx.doi.org/10.4314/bcse.v38i5.7

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

香兰素和 4-硝基苯胺衍生的希夫碱及其镍（II）配合物：光谱分析和抗菌研究

通过回流含有金属盐（NiCl2.6H2O，97.0%）和 SB 的乙醇溶液，以 1:2 M:L 的比例合成了 2-甲氧基-4-[（4-硝基苯基）亚氨基甲基]苯酚（MNIMP）的席夫碱（SB）配体 Ni(II) 金属络合物，并根据粉末（XRD）、核磁共振、傅立叶变换红外光谱、紫外可见分光光度计和理化测量结果对其进行了表征。傅立叶变换红外光谱显示，复合物通过双齿配体的偶氮甲基氮和酚氧配位。SB 的 1H-NMR 中的化学位移 δ = 9.8 ppm 与配体的偶氮甲基质子相对应，表明存在 -C=N- 连接，而 13C-NMR 则证实配体和复合物中存在 14C。与配体相比，络合物的紫外可见光谱波长变低，表明络合物已经形成。粉末 (XRD) 图样表明，镍（II）占据了八面体几何中心，从而形成了络合物的结晶相。络合物较高的摩尔电导值证实了它的电解性质。针对金黄色葡萄球菌和大肠杆菌这两种人类致病微生物，对合成化合物的体外抗菌活性进行了评估，并与标准药物庆大霉素进行了比较。结果表明，与游离的 MNIMP 配体相比，镍（II）复合物 [Ni (MNIMP)2(H2O)2]Cl2 对被测微生物的抑制面积更大。关键字：衍生物化，希夫碱配体，香兰素，镍（II）络合物，双齿，抗菌活性 Bull.埃塞俄比亚化学学会Soc.2024, 38(5), 1275-1289. DOI: https://dx.doi.org/10.4314/bcse.v38i5.7

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.