Tibial fracture arising from bone amyloidosis: A case study

JOS Case Reports Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI:10.1016/j.joscr.2024.07.002
Akane Yamamoto , Tomoaki Fukui , Takahiro Niikura , Kenichi Sawauchi , Masato Komatsu , Ryosuke Kuroda , Keisuke Oe
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Abstract

Background

Amyloidosis, a disease characterized by the deposition of abnormal proteins in various organs, leads to functional disorders. Here, we report the case of a 63-year-old man with AL amyloid deposition in the tibial shaft that resulted in a tibial fracture.

Case presentation

Amyloid bone cysts typically occur in the joints and vertebrae of patients undergoing hemodialysis; however, in this case, the patient was not undergoing dialysis, and the deposition site was the tibial shaft. We performed curettage and osteosynthesis using a plate, and satisfactory patient recovery was observed at a 1.5-year postoperative follow-up.

Conclusions

Amyloidosis may cause functional impairment due to amyloid deposits in multiple organs and other complications; therefore, systemic examination is necessary.
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骨淀粉样变性引起的胫骨骨折:病例研究
髓样变性是一种以不同器官中异常蛋白沉积为特征的疾病,可导致功能障碍。在此,我们报告一例63岁男性AL淀粉样蛋白沉积在胫骨干导致胫骨骨折的病例。淀粉样骨囊肿常见于血液透析患者的关节和椎骨;然而,在本例中,患者未进行透析,沉积部位为胫骨干。我们使用钢板进行刮除和植骨术,在术后1.5年随访中观察到患者恢复良好。结论淀粉样变性可引起多脏器淀粉样沉积及其他并发症导致功能损害;因此,系统检查是必要的。
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