The feasibility of atrial Fibrillatory wave amplitude in predicting ablation outcomes in persistent atrial fibrillation

IF 1.3 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of electrocardiology Pub Date : 2024-07-26 DOI:10.1016/j.jelectrocard.2024.153766

Linlin Wang MD , Gang Yang MD , Chang Cui MD , Xiangwei Ding MD , Weizhu Ju MD , Hailei Liu MD , Mingfang Li MD , Hongwu Chen MD , Kai Gu MD , Zidun Wang MD , Minglong Chen MD

{"title":"The feasibility of atrial Fibrillatory wave amplitude in predicting ablation outcomes in persistent atrial fibrillation","authors":"Linlin Wang MD , Gang Yang MD , Chang Cui MD , Xiangwei Ding MD , Weizhu Ju MD , Hailei Liu MD , Mingfang Li MD , Hongwu Chen MD , Kai Gu MD , Zidun Wang MD , Minglong Chen MD","doi":"10.1016/j.jelectrocard.2024.153766","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Atrial fibrosis has a significant impact on the success rate of catheter ablation (CA) treatment of atrial fibrillation (AF). The fibrotic tissues could be reflected by the amplitude of the fibrillatory wave (F-wave).</p></div><div><h3>Methods and Results</h3><p>704 patients with persistent AF and at least 1-year follow-up after CA were included as the internal group. 101 patients from another hospital were used as the external validation cohort. A 12‑lead ECG was performed before CA and the maximum FWA in three ECG leads (aVL, aVF, V1) were measured. The FWA score (0 to 6 points according to the amplitude range of the three leads) of each patients was calculated. Five models including clinical features, FWA score, CHA2DS2-VASc score, APPLE score and the fusion of clinical features and FWA score were built. The FWA score was superior to the model constructed by clinical variables, CHA2DS2-VASc score and APPLE score. It not only had good predictive performance for AF recurrence, with an AUC value of 0.812 (95% CI 0.724–0.900), but also showed a significant predictive value for the recurrence rate according to F-wave amplitude. In the external validation cohort, the FWA score showed similar results (AUC 0.768, 95% CI 0.672–0.865).</p></div><div><h3>Conclusions</h3><p>The present study reveals the significant predictive value of the FWA score for persistent AF ablation recurrence.</p></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of electrocardiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002207362400236X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Atrial fibrosis has a significant impact on the success rate of catheter ablation (CA) treatment of atrial fibrillation (AF). The fibrotic tissues could be reflected by the amplitude of the fibrillatory wave (F-wave).

Methods and Results

704 patients with persistent AF and at least 1-year follow-up after CA were included as the internal group. 101 patients from another hospital were used as the external validation cohort. A 12‑lead ECG was performed before CA and the maximum FWA in three ECG leads (aVL, aVF, V1) were measured. The FWA score (0 to 6 points according to the amplitude range of the three leads) of each patients was calculated. Five models including clinical features, FWA score, CHA2DS2-VASc score, APPLE score and the fusion of clinical features and FWA score were built. The FWA score was superior to the model constructed by clinical variables, CHA2DS2-VASc score and APPLE score. It not only had good predictive performance for AF recurrence, with an AUC value of 0.812 (95% CI 0.724–0.900), but also showed a significant predictive value for the recurrence rate according to F-wave amplitude. In the external validation cohort, the FWA score showed similar results (AUC 0.768, 95% CI 0.672–0.865).

Conclusions

The present study reveals the significant predictive value of the FWA score for persistent AF ablation recurrence.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

心房颤动波振幅预测持续性心房颤动消融结果的可行性

背景心房纤维化对心房颤动（房颤）导管消融（CA）治疗的成功率有显著影响。方法和结果 704 名持续性房颤患者被纳入内部组，并在导管消融术后随访至少 1 年。另一家医院的 101 名患者作为外部验证组。CA 前进行 12 导联心电图检查，测量三个心电图导联（aVL、aVF、V1）的最大 FWA。计算出每位患者的 FWA 分数（根据三个导联的振幅范围从 0 到 6 分不等）。建立了五个模型，包括临床特征、FWA 评分、CHA2DS2-VASc 评分、APPLE 评分以及临床特征与 FWA 评分的融合。FWA 评分优于由临床变量、CHA2DS2-VASc 评分和 APPLE 评分构建的模型。它不仅对房颤复发具有良好的预测性能，AUC 值为 0.812（95% CI 0.724-0.900），而且根据 F 波振幅对复发率具有显著的预测价值。结论本研究揭示了 FWA 评分对持续性房颤消融复发的显著预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of electrocardiology 医学-心血管系统

CiteScore

2.70

自引率

7.70%

发文量

152

审稿时长

38 days

期刊介绍： The Journal of Electrocardiology is devoted exclusively to clinical and experimental studies of the electrical activities of the heart. It seeks to contribute significantly to the accuracy of diagnosis and prognosis and the effective treatment, prevention, or delay of heart disease. Editorial contents include electrocardiography, vectorcardiography, arrhythmias, membrane action potential, cardiac pacing, monitoring defibrillation, instrumentation, drug effects, and computer applications.