A functional interplay between non-coding RNAs and cancer-associated fibroblasts in breast cancer

IF 1 Q4 GENETICS & HEREDITY Gene Reports Pub Date : 2024-07-22 DOI:10.1016/j.genrep.2024.101990

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Abstract

Breast cancer is the most common cancer among women worldwide. Early detection and treatment are essential to improve patient outcomes and reduce mortality. Fibroblasts play a significant role in breast cancer development. Fibroblasts can be activated and influenced by cancer cells, leading to their identification as cancerassociated fibroblasts (CAFs), which are essential for tumor progression. In breast cancer, CAFs, as the main population of the tumor microenvironment, play a vital role and control several biological processes through non-coding RNAs(ncRNA) and signaling pathways. NcRNAs, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), function as epigenetic regulators to control gene expression. Several studies have suggested that ncRNAs interfere in regulating tumor initiation and progression and can be used as biomarkers and therapeutic targets in different cancer types. Exosomes are extracellular vesicles that interact between fibroblasts and cancer cells. Exosomes derived from CAFs can influence breast cancer cells. Cancer cellderived exosomes may promote CAF phenotype, and CAF-derived exosomes transport miRNAs, lncRNAs, and several other substances, promoting breast cancer cell proliferation, migration, invasion, and angiogenesis, making them a potential therapeutic target. Despite little knowledge of the underlying functions of lncRNAs and miRNAs in CAFs, this review investigates how these ncRNAs cross-talk between tumor cells and CAFs.

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乳腺癌中的非编码 RNA 与癌症相关成纤维细胞之间的功能性相互作用

乳腺癌是全世界妇女最常见的癌症。早期发现和治疗对改善患者预后和降低死亡率至关重要。成纤维细胞在乳腺癌的发展过程中起着重要作用。成纤维细胞可被癌细胞激活并受其影响，从而被鉴定为癌相关成纤维细胞（CAFs），它们对肿瘤的发展至关重要。在乳腺癌中，CAFs 作为肿瘤微环境的主要群体，通过非编码 RNAs（ncRNA）和信号通路控制着多个生物学过程，并发挥着重要作用。NcRNA，如长非编码RNA（lncRNA）和microRNA（miRNA），是控制基因表达的表观遗传调节因子。一些研究表明，ncRNAs 可干预肿瘤的发生和发展，并可用作不同癌症类型的生物标志物和治疗靶点。外泌体是成纤维细胞和癌细胞之间相互作用的细胞外囊泡。来自成纤维细胞的外泌体可影响乳腺癌细胞。癌细胞衍生的外泌体可促进CAF表型，CAF衍生的外泌体可运输miRNAs、lncRNAs和其他一些物质，促进乳腺癌细胞的增殖、迁移、侵袭和血管生成，使其成为潜在的治疗靶点。尽管人们对CAF中lncRNA和miRNA的基本功能知之甚少，但本综述将探讨这些ncRNA如何在肿瘤细胞和CAF之间进行交叉对话。

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.